Targeting lipid metabolism with natural products: A novel strategy for gastrointestinal cancer therapy

C Guo, L Zhang, M Zhao, Y Ai, W Liao… - Phytotherapy …, 2023 - Wiley Online Library
Gastrointestinal cancer (GIC), including gastric cancer and colorectal cancer, is a common
malignant tumor originating from gastrointestinal epithelial cells. Although the pathogenesis …

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

MN Morshed, R Akter, MR Karim, S Iqbal… - Current Issues in …, 2024 - mdpi.com
Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural
abundance that is primarily produced by physicochemical processing, side chain …

Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress–mitophagy

M Yan, J Wang, H Wang, J Zhou, H Qi, Y Naji… - Journal of Translational …, 2023 - Springer
Background Clear cell renal cell carcinoma (ccRCC) is closely associated with steroid
hormones and their receptors affected by lipid metabolism. Recently, there has been …

Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy

W Li, H Li, L Zheng, J Xia, X Yang, S Men, Y Yuan… - Food & Function, 2023 - pubs.rsc.org
Skeletal muscle insulin resistance is the main cause of type 2 diabetes, and mitochondria
play a key role. Ginsenoside CK is the main active compound of ginseng with a variety of …

Ginsenoside compound K exerts anti-inflammatory effects through transcriptional activation and transcriptional inhibition of glucocorticoid receptor in rheumatoid …

M Yang, L Mao, X Yang, X Xu, C Tang, W Wei… - International …, 2023 - Elsevier
Ginsenoside compound K (GCK) has anti-inflammatory and immunoregulatory effects, and
glucocorticoid receptor (GR) has been considered as its potential target. But the mechanism …

[HTML][HTML] Co-morbid intersections of cancer and cardiovascular disease and targets for natural drug action: Reprogramming of lipid metabolism

G Zhu, L Cao, J Wu, M Xu, Y Zhang, M Wu… - Biomedicine & …, 2024 - Elsevier
Cancer and cardiovascular diseases are major contributors to global morbidity and mortality,
and their seemingly separate pathologies are intricately intertwined. In the context of cancer …

Natural activators of autophagy

JA Pavlova, EA Guseva, OA Dontsova… - Biochemistry (Moscow …, 2024 - Springer
Autophagy is the process by which cell contents, such as aggregated proteins, dysfunctional
organelles, and cell structures are sequestered by autophagosome and delivered to …

Ginsenoside–a promising natural active ingredient with steroidal hormone activity

J Li, J Zhao, X Wang, Z Lin, H Lin, Z Lin - Food & Function, 2024 - pubs.rsc.org
Ginsenosides are a class of natural products with hormone-like activity of triterpenoid
saponins and have a variety of pharmacological activities such as anti-aging, immune …

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

BD Ilieş, I Yildiz, M Abbas - ChemBioChem, 2024 - Wiley Online Library
Peptides have become an indispensable tool in engineering of multifunctional nanostructure
platforms for biomedical applications such as targeted drug and gene delivery, imaging and …

The sugar moiety in protopanaxadiol ginsenoside affects its ability to target glucocorticoid receptor to regulate lipid metabolism

W Li, L Zheng, X Ma, J Xia, J Sheng, P Ge, Y Yuan… - Bioorganic …, 2024 - Elsevier
Ginsenosides are natural products with hydrophobic rings adorned with sugar molecules.
The elucidation of the impact of ginsenosides structure on their activity is crucial for …