Targeting lipid metabolism with natural products: A novel strategy for gastrointestinal cancer therapy
C Guo, L Zhang, M Zhao, Y Ai, W Liao… - Phytotherapy …, 2023 - Wiley Online Library
Gastrointestinal cancer (GIC), including gastric cancer and colorectal cancer, is a common
malignant tumor originating from gastrointestinal epithelial cells. Although the pathogenesis …
malignant tumor originating from gastrointestinal epithelial cells. Although the pathogenesis …
Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases
Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural
abundance that is primarily produced by physicochemical processing, side chain …
abundance that is primarily produced by physicochemical processing, side chain …
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress–mitophagy
M Yan, J Wang, H Wang, J Zhou, H Qi, Y Naji… - Journal of Translational …, 2023 - Springer
Background Clear cell renal cell carcinoma (ccRCC) is closely associated with steroid
hormones and their receptors affected by lipid metabolism. Recently, there has been …
hormones and their receptors affected by lipid metabolism. Recently, there has been …
Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy
W Li, H Li, L Zheng, J Xia, X Yang, S Men, Y Yuan… - Food & Function, 2023 - pubs.rsc.org
Skeletal muscle insulin resistance is the main cause of type 2 diabetes, and mitochondria
play a key role. Ginsenoside CK is the main active compound of ginseng with a variety of …
play a key role. Ginsenoside CK is the main active compound of ginseng with a variety of …
Ginsenoside compound K exerts anti-inflammatory effects through transcriptional activation and transcriptional inhibition of glucocorticoid receptor in rheumatoid …
M Yang, L Mao, X Yang, X Xu, C Tang, W Wei… - International …, 2023 - Elsevier
Ginsenoside compound K (GCK) has anti-inflammatory and immunoregulatory effects, and
glucocorticoid receptor (GR) has been considered as its potential target. But the mechanism …
glucocorticoid receptor (GR) has been considered as its potential target. But the mechanism …
[HTML][HTML] Co-morbid intersections of cancer and cardiovascular disease and targets for natural drug action: Reprogramming of lipid metabolism
G Zhu, L Cao, J Wu, M Xu, Y Zhang, M Wu… - Biomedicine & …, 2024 - Elsevier
Cancer and cardiovascular diseases are major contributors to global morbidity and mortality,
and their seemingly separate pathologies are intricately intertwined. In the context of cancer …
and their seemingly separate pathologies are intricately intertwined. In the context of cancer …
Natural activators of autophagy
JA Pavlova, EA Guseva, OA Dontsova… - Biochemistry (Moscow …, 2024 - Springer
Autophagy is the process by which cell contents, such as aggregated proteins, dysfunctional
organelles, and cell structures are sequestered by autophagosome and delivered to …
organelles, and cell structures are sequestered by autophagosome and delivered to …
Ginsenoside–a promising natural active ingredient with steroidal hormone activity
J Li, J Zhao, X Wang, Z Lin, H Lin, Z Lin - Food & Function, 2024 - pubs.rsc.org
Ginsenosides are a class of natural products with hormone-like activity of triterpenoid
saponins and have a variety of pharmacological activities such as anti-aging, immune …
saponins and have a variety of pharmacological activities such as anti-aging, immune …
Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications
Peptides have become an indispensable tool in engineering of multifunctional nanostructure
platforms for biomedical applications such as targeted drug and gene delivery, imaging and …
platforms for biomedical applications such as targeted drug and gene delivery, imaging and …
The sugar moiety in protopanaxadiol ginsenoside affects its ability to target glucocorticoid receptor to regulate lipid metabolism
W Li, L Zheng, X Ma, J Xia, J Sheng, P Ge, Y Yuan… - Bioorganic …, 2024 - Elsevier
Ginsenosides are natural products with hydrophobic rings adorned with sugar molecules.
The elucidation of the impact of ginsenosides structure on their activity is crucial for …
The elucidation of the impact of ginsenosides structure on their activity is crucial for …