[HTML][HTML] Gut microbiota bridges dietary nutrients and host immunity
L Fan, Y Xia, Y Wang, D Han, Y Liu, J Li, J Fu… - Science China Life …, 2023 - Springer
Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and
entrain each other, and thus affect host health and immune-mediated diseases. Here, we …
entrain each other, and thus affect host health and immune-mediated diseases. Here, we …
Biotin, a universal and essential cofactor: synthesis, ligation and regulation
C Sirithanakorn, JE Cronan - FEMS Microbiology Reviews, 2021 - academic.oup.com
Biotin is a covalently attached enzyme cofactor required for intermediary metabolism in all
three domains of life. Several important human pathogens (eg Mycobacterium tuberculosis) …
three domains of life. Several important human pathogens (eg Mycobacterium tuberculosis) …
High‐quality genome‐scale metabolic modelling of Pseudomonas putida highlights its broad metabolic capabilities
Genome‐scale reconstructions of metabolism are computational species‐specific
knowledge bases able to compute systemic metabolic properties. We present a …
knowledge bases able to compute systemic metabolic properties. We present a …
[HTML][HTML] Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale
High titer, rate, yield (TRY), and scalability are challenging metrics to achieve due to trade-
offs between carbon use for growth and production. To achieve these metrics, we take the …
offs between carbon use for growth and production. To achieve these metrics, we take the …
Fatty acid and alcohol metabolism in Pseudomonas putida: functional analysis using random barcode transposon sequencing
With its ability to catabolize a wide variety of carbon sources and a growing engineering
toolkit, Pseudomonas putida KT2440 is emerging as an important chassis organism for …
toolkit, Pseudomonas putida KT2440 is emerging as an important chassis organism for …
RB-TnSeq identifies genetic targets for improved tolerance of Pseudomonas putida towards compounds relevant to lignin conversion
Lignin-derived mixtures intended for bioconversion commonly contain high concentrations
of aromatic acids, aliphatic acids, and salts. The inherent toxicity of these chemicals places a …
of aromatic acids, aliphatic acids, and salts. The inherent toxicity of these chemicals places a …
[HTML][HTML] Engineering Pseudomonas putida for efficient aromatic conversion to bioproduct using high throughput screening in a bioreactor
Pseudomonas putida KT2440 is an emerging biomanufacturing host amenable for use with
renewable carbon streams including aromatics such as para-coumarate. We used a pooled …
renewable carbon streams including aromatics such as para-coumarate. We used a pooled …
[HTML][HTML] Isocitrate dehydrogenase variants in cancer—Cellular consequences and therapeutic opportunities
S Liu, T Cadoux-Hudson, CJ Schofield - Current opinion in chemical …, 2020 - Elsevier
Abnormal metabolism is common in cancer cells and often correlates with mutations in
genes encoding for enzymes involved in small-molecule metabolism. Isocitrate …
genes encoding for enzymes involved in small-molecule metabolism. Isocitrate …
[HTML][HTML] An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
Z Kang, M Zhang, K Gao, W Zhang, W Meng… - Nature …, 2021 - nature.com
Abstract l-2-Hydroxyglutarate (l-2-HG) plays important roles in diverse physiological
processes, such as carbon starvation response, tumorigenesis, and hypoxic adaptation …
processes, such as carbon starvation response, tumorigenesis, and hypoxic adaptation …
[HTML][HTML] Filling gaps in bacterial catabolic pathways with computation and high-throughput genetics
To discover novel catabolic enzymes and transporters, we combined high-throughput
genetic data from 29 bacteria with an automated tool to find gaps in their catabolic pathways …
genetic data from 29 bacteria with an automated tool to find gaps in their catabolic pathways …