Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

Current COVID-19 pandemic poses an unprecedented threat to global health and
healthcare systems. The most amount of the death toll is accounted by old people affected …

To reveal if coagulopathies relate to the course of COVID-19, we examined 255 patients with
moderate and severe COVID-19, receiving anticoagulants and immunosuppressive drugs …

Lung injury may persist during the recovery period of COVID-19 as shown through imaging,
six-minute walk, and lung function tests. The pathophysiological mechanisms leading to …

Antimicrobials have allowed medical advancements over several decades. However, the
continuous emergence of antimicrobial resistance restricts efficacy in treating infectious …

Neutrophils are vital in defence against pathogens, but excessive neutrophil activity can
lead to tissue damage and promote acute respiratory distress syndrome. COVID-19 is …

Toll-like receptors (TLRs) have a critical role in the pathogenesis and disease course of viral
infections. The induced pro-inflammatory responses result in the disturbance of the …

This medical review addresses the hypothesis that CD38/NADase is at the center of a
functional axis (ie, intracellular Ca2+ mobilization/IFNγ response/reactive oxygen species …

A significant number of patients with coronavirus disease 2019 (COVID-19) develop acute
respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular …