Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Purinergic G-protein-coupled receptors are ancient and the most abundant group of G-
protein-coupled receptors (GPCRs). The wide distribution of purinergic receptors in the …

Two subtypes of G protein-coupled receptors for nucleotides (P 2U and P 2Y
purinoreceptors) contain several conserved positively charged amino acids in the third …

Extracellular ATP and ADP have been shown to exhibit potent angiogenic effects on
pulmonary artery adventitial vasa vasorum endothelial cells (VVEC). However, the …

The role of ATP and ADP as intercellular mediators is now well established. The presence of
the nucleotides in extracellular fluids can result from several mechanisms: cell lysis …

The reported effects of nitric oxide (NO) on dopamine release from the Striatum are variable
and its precise effect on striatal nerve terminals is unclear. In the present study a novel …

Purinergic receptors have been found to modulate ion transport in several types of epithelial
cells as well as excitable cells. It was of interest to determine whether vestibular dark cells …

Extracellular nucleotides are potent Ca2+ mobilizing agents. A variety of receptors for
extracellular ATP are recognised. Some are involved in fast neuronal transmission and …

1. Adenine nucleotides stimulate the synthesis and release of prostacyclin and nitric oxide
(two potent platelet aggregation inhibitors) by endothelial cells from different origins. These …

It was previously shown that K+ secretion by vestibular dark cell epithelium is under control
of G protein-coupled receptors of the P2Y family in the apical membrane that are activated …