Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …

Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Delivering cancer therapeutics to tumors necessitates their escape from the surrounding
blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer …

The blood–retina barrier (BRB) is the term used to define the properties of the retinal
capillaries and the retinal pigment epithelium (RPE), which separate the systemic circulation …

While most cancer nanomedicine is designed to eliminate cancer, the nanomaterial per se
can lead to the formation of micrometre-sized gaps in the blood vessel endothelial walls …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the
organism from chemical, microbial, and physical challenges which is indispensable for …

The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …

Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …