Differentiation of peptide isomers and epimers by radical-directed dissociation
TR Lambeth, RR Julian - Methods in Enzymology, 2019 - Elsevier
Isomerization and epimerization are spontaneously occurring modifications that represent
common pathways for age-related damage in proteins. These modifications accumulate …
common pathways for age-related damage in proteins. These modifications accumulate …
Photodissociation of TEMPO-modified peptides: new approaches to radical-directed dissociation of biomolecules
Radical-directed dissociation of gas phase ions is emerging as a powerful and
complementary alternative to traditional tandem mass spectrometric techniques for …
complementary alternative to traditional tandem mass spectrometric techniques for …
Photoinitiated intramolecular diradical cross-linking of polyproline peptides in the gas phase
X Zhang, RR Julian - Physical Chemistry Chemical Physics, 2012 - pubs.rsc.org
Polyproline is a fascinating polymer with interesting structural properties that have been
studied in both solution and the gas phase. Herein, a method capable of measuring …
studied in both solution and the gas phase. Herein, a method capable of measuring …
Differentiation of peptide isomers by excited-state photodissociation and ion–molecule interactions
Solvochromatic effects are most frequently associated with solution-phase phenomena.
However, in the gas phase, the absence of solvent leads to intramolecular solvation that can …
However, in the gas phase, the absence of solvent leads to intramolecular solvation that can …
Exploring radical migration pathways in peptides with positional isomers, deuterium labeling, and molecular dynamics simulations
X Zhang, RR Julian - Journal of The American Society for Mass …, 2013 - ACS Publications
One of the keys for understanding radical directed dissociation in peptides is a detailed
knowledge of the factors that mediate radical migration. Peptide radicals can be created by a …
knowledge of the factors that mediate radical migration. Peptide radicals can be created by a …
Comparing positively and negatively charged distonic radical ions in phenylperoxyl forming reactions
PE Williams, DL Marshall, BLJ Poad… - Journal of the …, 2018 - ACS Publications
In the gas phase, arylperoxyl forming reactions play a significant role in low-temperature
combustion and atmospheric processing of volatile organic compounds. We have previously …
combustion and atmospheric processing of volatile organic compounds. We have previously …
Identification of inherently antioxidant regions in proteins with radical-directed dissociation mass spectrometry
Antioxidant peptides such as glutathione play critically important roles within cells by
opposing the action of oxidative species. Similarly all proteins may, as a secondary function …
opposing the action of oxidative species. Similarly all proteins may, as a secondary function …
Strategies for generating peptide radical cations via ion/ion reactions
Several approaches for the generation of peptide radical cations using ion/ion reactions
coupled with either collision induced dissociation (CID) or ultraviolet photo dissociation …
coupled with either collision induced dissociation (CID) or ultraviolet photo dissociation …
The innate capacity of proteins to protect against reactive radical species
Maintaining redox homeostasis, or the balance of oxidant and antioxidant forces, is essential
for proper cellular functioning in biology. Although the antioxidant nature of many small …
for proper cellular functioning in biology. Although the antioxidant nature of many small …
Leveraging electron transfer dissociation for site selective radical generation: applications for peptide epimer analysis
Traditional electron-transfer dissociation (ETD) experiments operate through a complex
combination of hydrogen abundant and hydrogen deficient fragmentation pathways, yielding …
combination of hydrogen abundant and hydrogen deficient fragmentation pathways, yielding …