Drug Discovery in the Field of β-Lactams: An Academic Perspective
LMC Jacobs, P Consol, Y Chen - Antibiotics, 2024 - mdpi.com
β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding
proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis. A …
proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis. A …
X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model
J Mou, XL Ning, XY Wang, SY Hou… - Journal of Medicinal …, 2024 - ACS Publications
The secretory glutaminyl cyclase (sQC) and Golgi-resident glutaminyl cyclase (gQC) are
responsible for N-terminal protein pyroglutamation and associated with various human …
responsible for N-terminal protein pyroglutamation and associated with various human …