In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase

L Shang, H Wei, J Deng, MJ Stewart, JE LeSaint… - Scientific Reports, 2024 - nature.com
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …

Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats

H Wei, JE LeSaint, Z Jin, CG Zhan, F Zheng - Scientific Reports, 2024 - nature.com
Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …