Vascularized microfluidic models of major organ structures and cancerous tissues
A Rama Varma, P Fathi - Biomicrofluidics, 2023 - pubs.aip.org
Organ-on-a-chip devices are powerful modeling systems that allow researchers to
recapitulate the in vivo structures of organs as well as the physiological conditions those …
recapitulate the in vivo structures of organs as well as the physiological conditions those …
Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches
MW Laschke, Y Gu, MD Menger - Frontiers in physiology, 2022 - frontiersin.org
Angiogenesis, the development of new blood vessels from pre-existing ones, is an essential
process determining numerous physiological and pathological conditions. Accordingly …
process determining numerous physiological and pathological conditions. Accordingly …
Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
K Miki, M Yagi, K Yoshimoto, D Kang, T Uchiumi - Oncogenesis, 2022 - nature.com
Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal
circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial …
circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial …
Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease
N Shirozu, M Ohgidani, N Hata, S Tanaka, S Inamine… - Scientific reports, 2023 - nature.com
Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2
polarized microglia in ischemic stroke, suggesting that microglia may be involved in the …
polarized microglia in ischemic stroke, suggesting that microglia may be involved in the …
Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system
A Barry, SF Samuel, I Hosni, A Moursi, L Feugere… - Lab on a Chip, 2023 - pubs.rsc.org
Arginine methylation is a post-translational modification that consists of the transfer of one or
two methyl (CH3) groups to arginine residues in proteins. Several types of arginine …
two methyl (CH3) groups to arginine residues in proteins. Several types of arginine …
Vascularized tumor-on-chip microplatforms for the studies of neovasculature as hope for more effective cancer treatments.
J Konopka, A Żuchowska, E Jastrzębska - Biosensors and Bioelectronics, 2023 - Elsevier
Angiogenesis is the development of new blood vessels from pre-existing vasculature.
Multiple factors control its course. Disorders of the distribution of angiogenic agents are …
Multiple factors control its course. Disorders of the distribution of angiogenic agents are …
Differential P-glycoprotein/CD31 expression as markers of vascular co-option in primary central nervous system tumors
Background: Vascular co-option is one of the main features of brain tumor progression. It is
identified using histopathological analysis, but no antibody-specific markers were found, and …
identified using histopathological analysis, but no antibody-specific markers were found, and …
Glioblastoma Vasculature: From its Critical Role in Tumor Survival to Relevant in Vitro Modelling
Biochemical and biophysical cues governing glioblastoma (GBM) progression are complex
and dynamic. Tumor blood vessels, often recognized only by their transport functions, are …
and dynamic. Tumor blood vessels, often recognized only by their transport functions, are …
The Edifice of Vasculature-On-Chips: A Focused Review on the Key Elements and Assembly of Angiogenesis Models
The conception of vascularized organ-on-a-chip models provides researchers with the
ability to supply controlled biological and physical cues that simulate the in vivo dynamic …
ability to supply controlled biological and physical cues that simulate the in vivo dynamic …
Investigating Trans-differentiation of Glioblastoma Cells in an In Vitro 3D Model of the Perivascular Niche
RR Hatlen, P Rajagopalan - ACS Biomaterials Science & …, 2023 - ACS Publications
Glioblastoma multiforme (GBM) is the deadliest form of brain cancer, responsible for over
50% of adult brain tumors. A specific region within the GBM environment is known as the …
50% of adult brain tumors. A specific region within the GBM environment is known as the …