Vascularized microfluidic models of major organ structures and cancerous tissues

A Rama Varma, P Fathi - Biomicrofluidics, 2023 - pubs.aip.org
Organ-on-a-chip devices are powerful modeling systems that allow researchers to
recapitulate the in vivo structures of organs as well as the physiological conditions those …

Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches

MW Laschke, Y Gu, MD Menger - Frontiers in physiology, 2022 - frontiersin.org
Angiogenesis, the development of new blood vessels from pre-existing ones, is an essential
process determining numerous physiological and pathological conditions. Accordingly …

Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation

K Miki, M Yagi, K Yoshimoto, D Kang, T Uchiumi - Oncogenesis, 2022 - nature.com
Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal
circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial …

Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease

N Shirozu, M Ohgidani, N Hata, S Tanaka, S Inamine… - Scientific reports, 2023 - nature.com
Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2
polarized microglia in ischemic stroke, suggesting that microglia may be involved in the …

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system

A Barry, SF Samuel, I Hosni, A Moursi, L Feugere… - Lab on a Chip, 2023 - pubs.rsc.org
Arginine methylation is a post-translational modification that consists of the transfer of one or
two methyl (CH3) groups to arginine residues in proteins. Several types of arginine …

Vascularized tumor-on-chip microplatforms for the studies of neovasculature as hope for more effective cancer treatments.

J Konopka, A Żuchowska, E Jastrzębska - Biosensors and Bioelectronics, 2023 - Elsevier
Angiogenesis is the development of new blood vessels from pre-existing vasculature.
Multiple factors control its course. Disorders of the distribution of angiogenic agents are …

Differential P-glycoprotein/CD31 expression as markers of vascular co-option in primary central nervous system tumors

T Annese, M Errede, A d'Amati, M De Giorgis… - Diagnostics, 2022 - mdpi.com
Background: Vascular co-option is one of the main features of brain tumor progression. It is
identified using histopathological analysis, but no antibody-specific markers were found, and …

Glioblastoma Vasculature: From its Critical Role in Tumor Survival to Relevant in Vitro Modelling

C Pacheco, C Martins, J Monteiro, F Baltazar… - Frontiers in Drug …, 2022 - frontiersin.org
Biochemical and biophysical cues governing glioblastoma (GBM) progression are complex
and dynamic. Tumor blood vessels, often recognized only by their transport functions, are …

The Edifice of Vasculature-On-Chips: A Focused Review on the Key Elements and Assembly of Angiogenesis Models

J Lim, HW Fang, S Bupphathong… - ACS Biomaterials …, 2024 - ACS Publications
The conception of vascularized organ-on-a-chip models provides researchers with the
ability to supply controlled biological and physical cues that simulate the in vivo dynamic …

Investigating Trans-differentiation of Glioblastoma Cells in an In Vitro 3D Model of the Perivascular Niche

RR Hatlen, P Rajagopalan - ACS Biomaterials Science & …, 2023 - ACS Publications
Glioblastoma multiforme (GBM) is the deadliest form of brain cancer, responsible for over
50% of adult brain tumors. A specific region within the GBM environment is known as the …