[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
An Overview of Methods and Tools for Transfection of Eukaryotic Cells in vitro
A Fus-Kujawa, P Prus, K Bajdak-Rusinek… - … in bioengineering and …, 2021 - frontiersin.org
Transfection is a powerful analytical tool enabling studies of gene products and functions in
eukaryotic cells. Successful delivery of genetic material into cells depends on DNA quantity …
eukaryotic cells. Successful delivery of genetic material into cells depends on DNA quantity …
Viral vectors in gene therapy: Where do we stand in 2023?
K Lundstrom - Viruses, 2023 - mdpi.com
Viral vectors have been used for a broad spectrum of gene therapy for both acute and
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …
Adenoviral vector-based vaccine platform for COVID-19: Current status
The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the
21st century, claiming millions of lives and putting a huge burden on the global economy …
21st century, claiming millions of lives and putting a huge burden on the global economy …
[HTML][HTML] Novel vectors and approaches for gene therapy in liver diseases
S Maestro, ND Weber, N Zabaleta, R Aldabe… - JHEP Reports, 2021 - Elsevier
Gene therapy is becoming an increasingly valuable tool to treat many genetic diseases with
no or limited treatment options. This is the case for hundreds of monogenic metabolic …
no or limited treatment options. This is the case for hundreds of monogenic metabolic …
Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges
M Asmamaw Mengstie - Frontiers in Bioengineering and …, 2022 - frontiersin.org
The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and its
accompanying protein (Cas9) are now the most effective, efficient, and precise genome …
accompanying protein (Cas9) are now the most effective, efficient, and precise genome …
Appraisal for the potential of viral and nonviral vectors in gene therapy: A review
Over the past few decades, gene therapy has gained immense importance in medical
research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer's …
research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer's …
Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed
biomedical research and provided entirely new models to analyze every aspect of …
biomedical research and provided entirely new models to analyze every aspect of …
Significance of preexisting vector immunity and activation of innate responses for adenoviral vector-based therapy
An adenoviral (AdV)-based vector system is a promising platform for vaccine development
and gene therapy applications. Administration of an AdV vector elicits robust innate …
and gene therapy applications. Administration of an AdV vector elicits robust innate …
Oncolytic virotherapy in glioma tumors
S Rius-Rocabert, N García-Romero, A García… - International Journal of …, 2020 - mdpi.com
Glioma tumors are one of the most devastating cancer types. Glioblastoma is the most
advanced stage with the worst prognosis. Current therapies are still unable to provide an …
advanced stage with the worst prognosis. Current therapies are still unable to provide an …