The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa
In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas
aeruginosa infections has gradually decreased. This pathogen can be observed in several …
aeruginosa infections has gradually decreased. This pathogen can be observed in several …
Molecular mechanisms underlying bacterial persisters
E Maisonneuve, K Gerdes - Cell, 2014 - cell.com
All bacteria form persisters, cells that are multidrug tolerant and therefore able to survive
antibiotic treatment. Due to the low frequencies of persisters in growing bacterial cultures …
antibiotic treatment. Due to the low frequencies of persisters in growing bacterial cultures …
Biofilm infections, their resilience to therapy and innovative treatment strategies
U Römling, C Balsalobre - Journal of internal medicine, 2012 - Wiley Online Library
Biofilm formation of microorganisms causes persistent tissue and foreign body infections
resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are …
resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are …
Broad-spectrum anti-biofilm peptide that targets a cellular stress response
C De la Fuente-Núñez, F Reffuveille, EF Haney… - PLoS …, 2014 - journals.plos.org
Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
RETRACTED:(p) ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity
E Maisonneuve, M Castro-Camargo, K Gerdes - Cell, 2013 - cell.com
Persistence refers to the phenomenon in which isogenic populations of antibiotic-sensitive
bacteria produce rare cells that transiently become multidrug tolerant. Whether slow growth …
bacteria produce rare cells that transiently become multidrug tolerant. Whether slow growth …
The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life
GC Atkinson, T Tenson, V Hauryliuk - PloS one, 2011 - journals.plos.org
RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and
SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize …
SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize …
ppGpp: magic beyond RNA polymerase
ZD Dalebroux, MS Swanson - Nature Reviews Microbiology, 2012 - nature.com
During stress, bacteria undergo extensive physiological transformations, many of which are
coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by …
coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by …
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP,(p) ppGpp signaling in bacteria and implications in pathogenesis
For an organism to survive, it must be able to sense its environment and regulate
physiological processes accordingly. Understanding how bacteria integrate signals from …
physiological processes accordingly. Understanding how bacteria integrate signals from …