The development of efflux pump inhibitors to treat Gram-negative infections
P Blanco, F Sanz-García… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: One of the possibilities for reducing the emergence and spread of antibiotic
resistance is the use of anti-resistance compounds capable of resensitizing resistant …
resistance is the use of anti-resistance compounds capable of resensitizing resistant …
Drug Resistance Reversal Potential of Ursolic Acid Derivatives against Nalidixic Acid‐ and Multidrug‐resistant Escherichia coli
GR Dwivedi, A Maurya, DK Yadav… - Chemical biology & …, 2015 - Wiley Online Library
As a part of our drug discovery program, ursolic acid was chemically transformed into six
semi‐synthetic derivatives, which were evaluated for their antibacterial and drug resistance …
semi‐synthetic derivatives, which were evaluated for their antibacterial and drug resistance …
Antibiotics potentiating potential of catharanthine against superbug Pseudomonas aeruginosa
GR Dwivedi, R Tyagi, null Sanchita… - Journal of …, 2018 - Taylor & Francis
Multidrug resistance (MDR) put an alarming situation like preantibiotic era which compels us
to invigorate the basic science of anti-infective chemotherapy. Hence, the drug resistant …
to invigorate the basic science of anti-infective chemotherapy. Hence, the drug resistant …
[HTML][HTML] Coumarin-1, 2, 3-triazole hybrids as leading-edge anticancer agents
KN Mishra, HC Upadhyay - Frontiers in Drug Discovery, 2022 - frontiersin.org
Cancer is one of the most feared and dreaded diseases across the world. In clinical practice,
a variety of anticancer agents of natural, semi-synthetic and synthetic origin exist, but they …
a variety of anticancer agents of natural, semi-synthetic and synthetic origin exist, but they …
Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance
Y Wang, R Mowla, L Guo, AD Ogunniyi… - Bioorganic & Medicinal …, 2017 - Elsevier
Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these
pumps important drug targets. We have synthesised a novel series of compounds based on …
pumps important drug targets. We have synthesised a novel series of compounds based on …
[HTML][HTML] Drug resistance reversal potential of multifunctional thieno [3, 2-c] pyran via potentiation of antibiotics in MDR P. aeruginosa
GR Dwivedi, R Rai, R Pratap, K Singh, S Pati… - Biomedicine & …, 2021 - Elsevier
We explored the antibacterial potential (alone and combination) against multidrug resistant
(MDR) Pseudomonas aeruginosa isolates KG-P2 using synthesized thieno [3, 2-c] pyran-2 …
(MDR) Pseudomonas aeruginosa isolates KG-P2 using synthesized thieno [3, 2-c] pyran-2 …
New tools to mitigate drug resistance in Enterobacteriaceae – Escherichia coli and Klebsiella pneumoniae
NS Sundaramoorthy, P Shankaran… - Critical Reviews in …, 2023 - Taylor & Francis
Abstract Treatment to common bacterial infections are becoming ineffective of late, owing to
the emergence and dissemination of antibiotic resistance globally. Escherichia coli and …
the emergence and dissemination of antibiotic resistance globally. Escherichia coli and …
Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton
K Sheng, Y Song, F Lei, W Zhao, L Fan, L Wu… - European journal of …, 2022 - Elsevier
The tetralone and tetralone derivatives, as crucial structural scaffolds of potential novel
drugs targeted at multiple biological end-points, are normally found in several natural …
drugs targeted at multiple biological end-points, are normally found in several natural …
Medicinal chemistry updates on bacterial efflux pump modulators
F Durães, M Pinto, E Sousa - Current Medicinal Chemistry, 2018 - ingentaconnect.com
Antibiotic resistance is one of the most pressing health issues of our days. It can arise due to
a multiplicity of factors, such as target modification, decrease in the drug uptake, changes in …
a multiplicity of factors, such as target modification, decrease in the drug uptake, changes in …
[HTML][HTML] Detection of adeABC efllux pump encoding genes and antimicrobial effect of Mentha longifolia and Menthol on MICs of imipenem and ciprofloxacin in clinical isolates …
H Mahmoudi, L Shokoohizadeh, N Zare Fahim… - … medicine and therapies, 2020 - Springer
Background Acinetobacter baumannii is an opportunistic pathogen that causes nosocomial
infections especially in patients in intensive care units (ICUs). Accordingly, the aim of our …
infections especially in patients in intensive care units (ICUs). Accordingly, the aim of our …