The FMN-dependent two-component monooxygenase systems catalyze a diverse range of
reactions. These two-component systems are composed of an FMN reductase enzyme and …

The bacterial alkanesulfonate monooxygenase system is involved in the acquisition of sulfur
from organosulfonated compounds during limiting sulfur conditions. The reaction relies on …

Over 100 genome-scale metabolic networks (GSMNs) have been published in recent years
and widely used for phenotype prediction and pathway design. However, GSMNs for a …

Substrate-induced conformational changes present in alkanesulfonate monooxygenase
(SsuD) are crucial to catalysis and lead to distinct interactions between a dynamic loop …

The alkanesulfonate monooxygenase enzyme (SsuD) catalyzes the oxygenolytic cleavage
of a carbon–sulfur bond from sulfonated substrates. A mechanism involving acid–base …

The alkanesulfonate monooxygenase system catalyzes the desulfonation of
alkanesulfonates through proposed acid–base mechanistic steps that involves the …

The complex mechanistic properties of alkanesulfonate monooxygenase (SsuD) provide a
particular challenge for identifying catalytically relevant amino acids. In response, a joint …

The mechanism and substrate specificity of alkanesulfonate monooxygenase (SsuD) was
investigated by combining molecular dynamics simulations, docking, and a comprehensive …

All organisms require sulfur for diverse metabolic and physiological processes. Unlike
mammals, bacteria are often deprived of sulfur in their natural habitat and express various …

Bacteria two-component flavin-dependent systems are upregulated for sulfur acquisition
under sulfur limiting conditions. Two-component flavin-dependent systems are comprised of …