Genomic instability facilitates the evolution of cells, tissues, organs, and species. The
progression of human malignancies can be regarded as the accumulation of genomic …

Phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin inhibitor (mTOR)
pathway is often constitutively activated in human tumor cells and thus has been considered …

Background Famitinib is a tyrosine kinase inhibitor against multiple targets, including
vascular endothelial growth factor receptor 2/3, platelet‐derived growth factor receptor, and …

Nasopharyngeal carcinoma (NPC) is a common tumor in Southern China, but the oncogene
mutational status of NPC patients has not been clarified. Using time-of-flight mass …

Background Chemoresistance is an obstacle to the successful treatment of nasopharyngeal
carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also …

Oncogene mutations contribute to carcinogenesis and can provide potential therapeutic
targets for clinical anticancer management. However, oncogene mutation patterns in …

Introduction An increasing number of targeted drugs have been tested for the treatment of
nasopharyngeal carcinoma (NPC). However, targeted therapy-related oncogenic mutations …

Clear cell sarcoma (CCS) of tendons and aponeuroses is an aggressive neoplasm that is
characterized by a pathognomonic translocation, t (12; 22)(q13; q12), resulting in an EWSR1 …

简要分析了" 十一五" 期间国家高技术研究发展计划(" 863" 计划)" 重大疾病的分子分型和个体化
诊疗" 重大项目的课题设置及实施情况. 分别从本项目研究方向及课题设置, 课题承担单位及研究 …

1 * Corresponding author: Eric W.-F. Lam, Department of Surgery and Cancer, Imperial College
London, Hammersmith Hospital Campus Page 1 1 Lapatinib sensitivity in nasopharyngeal …