Effects of alpha-fetoprotein on the occurrence and progression of hepatocellular carcinoma

Y Zheng, M Zhu, M Li - Journal of cancer research and clinical oncology, 2020 - Springer
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world.
Alpha-fetoprotein (AFP) is considered as a diagnostic and prognostic tumorous marker for …

Transcription factor Fli-1 as a new target for antitumor drug development

L Li, J Yu, S Cheng, Z Peng, H Luo - International Journal of Biological …, 2022 - Elsevier
The transcription factor Friend leukemia virus integration 1 (Fli-1) belonging to the E26
Transformation-Specific (ETS) transcription factor family is not only expressed in normal …

Overexpression of SLC25A51 promotes hepatocellular carcinoma progression by driving aerobic glycolysis through activation of SIRT5

L Bai, ZX Yang, PF Ma, JS Liu, DS Wang… - Free Radical Biology and …, 2022 - Elsevier
Solute carrier family 25 member 20 (SLC25A51) is a newly identified mammalian
mitochondrial NAD+ transporter. However, the clinicopathological and biological …

Matrix metalloproteinase 2 is a target of the RAN-GTP pathway and mediates migration, invasion and metastasis in human breast cancer

M El-Tanani, A Platt-Higgins, YF Lee, AO Al Khatib… - Life Sciences, 2022 - Elsevier
RAS-related nuclear protein (RAN) is a nuclear shuttle and normally regulates events in the
cell cycle. When overexpressed in cultured cells, it causes increases in cell …

[HTML][HTML] Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment

N Pavlović, M Kopsida, P Gerwins, F Heindryckx - Life sciences, 2021 - Elsevier
Aim Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in a
background of chronic liver disease and prolonged inflammation. A major contributor in the …

[HTML][HTML] Generation and characterization of cytochrome P450 3A74 CRISPR/Cas9 knockout bovine foetal hepatocyte cell line (BFH12)

S Iori, C D'Onofrio, N Laham-Karam… - Biochemical …, 2024 - Elsevier
In human, the cytochrome P450 3A (CYP3A) subfamily of drug-metabolizing enzymes
(DMEs) is responsible for a significant number of phase I reactions, with the CYP3A4 isoform …

[HTML][HTML] FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer

PY Guneri-Sozeri, G Özden-Yılmaz, A Kisim… - Communications …, 2023 - nature.com
Bladder cancer is mostly present in the form of urothelium carcinoma, causing over 150,000
deaths each year. Its histopathological classification as muscle invasive (MIBC) and non …

Tumor microenvironment acidity modulates ROR1 to promote epithelial–mesenchymal transition and hepatocarcinoma metastasis

X Meng, Y Xu, X Ning - Journal of Cell Science, 2021 - journals.biologists.com
The tendency of hepatocarcinoma to metastasize results in a high rate of mortality, making it
a hot research topic in cancer studies. Although an acidic tumor microenvironment has been …

MicroRNA‐33b regulates hepatocellular carcinoma cell proliferation, apoptosis, and mobility via targeting Fli‐1‐mediated Notch1 pathway

H Wang, X Lin, E Liu, Z Jian… - Journal of Cellular …, 2020 - Wiley Online Library
MicroRNAs (miRNAs) have been confirmed to play pivotal roles in hepatocellular carcinoma
(HCC) carcinogenesis. However, the underlying function of microRNA‐33b (miR‐33b) in …

The gene signature associated with hepatocellular carcinoma in patients with nonalcoholic fatty liver disease

J Ge, Y Bai, B Tang, D Wei, M Yan - Journal of Oncology, 2021 - Wiley Online Library
Background. Nonalcoholic fatty liver disease (NAFLD) is becoming a critical risk of
hepatocellular carcinoma (HCC). As both NAFLD and HCC are heterogeneous diseases …