[HTML][HTML] Novel drug targets and emerging pharmacotherapies in neuropathic pain
J Bernatoniene, A Sciupokas, DM Kopustinskiene… - Pharmaceutics, 2023 - mdpi.com
Neuropathic pain is a debilitating condition characterized by abnormal signaling within the
nervous system, resulting in persistent and often intense sensations of pain. It can arise from …
nervous system, resulting in persistent and often intense sensations of pain. It can arise from …
[HTML][HTML] Degranulation of human mast cells: modulation by P2 receptors' agonists
ES Schulman, H Nishi, A Pelleg - Frontiers in immunology, 2023 - frontiersin.org
Since the late 1970s, there has been an alarming increase in the incidence of asthma and
its morbidity and mortality. Acute obstruction and inflammation of allergic asthmatic airways …
its morbidity and mortality. Acute obstruction and inflammation of allergic asthmatic airways …
[HTML][HTML] Overview of the role of purinergic signaling and insights into its role in cancer therapy
F Di Virgilio, V Vultaggio-Poma, M Tarantini… - Pharmacology & …, 2024 - Elsevier
Innovation of cancer therapy has received a dramatic acceleration over the last fifteen years
thanks to the introduction of the novel immune checkpoint inhibitors (ICI). On the other hand …
thanks to the introduction of the novel immune checkpoint inhibitors (ICI). On the other hand …
[HTML][HTML] Metabolomics-based alleviation of depression by Xiaoyaosan through regulation of XDH and GRIA2
C Lei, Y Liu, Q Ma, Z Chen, Q Kong, Y Jia… - Pharmacological …, 2023 - Elsevier
Background Xiaoyaosan is gradually gaining acceptance and recognition within the
international scientific community. However, it still lacks appropriate methodological and …
international scientific community. However, it still lacks appropriate methodological and …
Purinergic signalling: 50 years
P Illes, F Di Virgilio, Y Tang - Neuropharmacology, 2023 - Elsevier
The function of almost all cells of the human and animal body is synchronized by purinergic/
pyrimidinergic extracellular signaling molecules. This network activity is especially efficient …
pyrimidinergic extracellular signaling molecules. This network activity is especially efficient …
Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?
JM Witkin, H Shafique, JL Smith - Biochemical Pharmacology, 2024 - Elsevier
Patients with epilepsy require improved medications. Purinergic receptors were identified as
late as 1976 and are slowly emerging as potential drug targets for the discovery of …
late as 1976 and are slowly emerging as potential drug targets for the discovery of …
[HTML][HTML] Commentary: P2X7 receptor modulation is a viable therapeutic target for neurogenic pain with concurrent sleep disorders
S Shah, K Kondapalli, N Rasheed… - Frontiers in Neuroscience, 2023 - frontiersin.org
Chronic neuropathic pain can severely impact people's quality of life, influencing their mood,
activities of daily living, sleep, and cognition. In comparison to the general population …
activities of daily living, sleep, and cognition. In comparison to the general population …
Drug receptor interactions
Drug receptor interactions form the bedrock of pharmacology and underlies the foundation
of therapeutic management and interventions in contemporary medicine. This chapter gives …
of therapeutic management and interventions in contemporary medicine. This chapter gives …
Targeting the ATP-Axis in Lungs as a New Therapheutic Modality for COPD
A Pelleg, PJ Barnes, ES Schulman - Medical Research Archives, 2023 - esmed.org
Abstract Adenosine 5'-triphosphate (ATP) is found in every cell of the body where it plays a
critical role in cellular metabolism and energetics. ATP is released from cells under …
critical role in cellular metabolism and energetics. ATP is released from cells under …
[PDF][PDF] Novel Drug Targets and Emerging Pharmacotherapies in Neuropathic Pain. Pharmaceutics 2023, 15, 1799
J Bernatoniene, A Sciupokas, DM Kopustinskiene… - 2023 - academia.edu
Neuropathic pain is a debilitating condition characterized by abnormal signaling within the
nervous system, resulting in persistent and often intense sensations of pain. It can arise from …
nervous system, resulting in persistent and often intense sensations of pain. It can arise from …