Oncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic
malignancies and together predict a limited responsiveness to conventional chemotherapy …

Hormone receptor positive breast cancer (HR-positive BC) is the most frequent BC subtype
(∼ 70%), with endocrine treatment constituting its therapeutic cornerstone; despite its …

Purpose Multi-gene signatures provide biological insight and risk stratification in breast
cancer. Intrinsic molecular subtypes defined by mRNA expression of 50 genes (PAM50) are …

Metformin is widely prescribed for the treatment of type II diabetes. Recently, it has been
proposed that this compound or related biguanides may have antineoplastic activity …

Locally advanced breast cancer (LABC) constitutes a heterogeneous entity that includes
advanced-stage primary tumours, cancers with extensive nodal involvement and …

Purpose. Breast cancer (BC) is a disease of aging and the number of older BC patients in
the US is rising. Immunohistochemical data show that with increasing age, the incidence of …

The treatment of breast cancer has evolved from a primary surgical approach with a focus on
local-regional control to multidisciplinary management with an emphasis on systemic …

These NCCN Guideline Insights highlight the important updates to the systemic therapy
recommendations in the 2016 NCCN Guidelines for Breast Cancer. In the most recent …

Purpose To describe estradiol (E2), estrone (E1), and estrone sulfate (E1S) levels during the
first year of monthly triptorelin plus exemestane or tamoxifen and to assess possible …

RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts
in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis …