The number of cancer cases caused by being obese is estimated to be 20% with the
increased risk of malignancies being influenced by diet, weight change, and body fat …

There is increasing evidence showing that inflammation is an important pathogenic mediator
of the development of obesity-induced insulin resistance. It is now generally accepted that …

Adipose tissue (AT) of obese mice and humans accumulates immune cells, which secrete
cytokines that can promote insulin resistance. AT macrophages (ATMs) are thought to …

Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …

The Mediterranean diet pattern is increasingly associated with improved metabolic health.
Two mechanisms by which consuming a Mediterranean diet pattern may contribute to …

Objective This study characterized the kynurenine pathway (KP) in human obesity by
evaluating circulating levels of kynurenines and the expression of KP enzymes in adipose …

A number of approaches have been utilized in the prevention, management, and treatment
of obesity, including, surgery, medication, diet, exercise, and overall lifestyle changes …

In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB
(glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with …

Macrophages are extremely versatile cells that adopt a distinct phenotype in response to a
changing microenvironment. Consequently, macrophages are involved in diverse functions …

There is compelling epidemiological evidence linking obesity to many tumours; however, the
molecular mechanisms fuelling this association are not clearly understood. Emerging …