Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Major depressive disorder (MDD) is a common mental disorder with a high rate of morbidity
and mortality. Dysfunctional signaling of gamma-aminobutyric acid (GABA) has been …

Background: Tremor is one of the most prevalent symptoms in Parkinson's Disease (PD).
The progression and management of tremor in PD can be challenging, as response to …

GABAkines, or positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors,
are used for the treatment of anxiety, epilepsy, sleep, and other disorders. The search for …

Motor symptoms are a core feature of Parkinson's disease (PD) and cause a significant
burden on patients' quality of life. Oral levodopa is still the most effective treatment, however …

Zuranolone (ZURZUVAE™) is an oral neuroactive steroid and a positive allosteric modulator
of the gamma aminobutyric acid A (GABAA) receptor being developed by Sage …

With each passing year, the number of people suffering from mental disorders grows at a
disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential …

Preterm birth results in an increased risk of neonatal brain injury and neurobehavioural
disorders. Despite the seriousness of these adverse outcomes, there are currently no …

Nondopaminergic neurotransmitters such as adenosine, norepinephrine, serotonin,
glutamate, and acetylcholine are all involved in Parkinson's disease (PD) and promote its …

Ketamine, in research settings, rapidly reduces suicidal thoughts 2–24 h after a single
infusion in patients with high suicidal ideation. In this study, the authors investigate …