The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

Schultz, BD, AK Singh, DC Devor, and RJ Bridges. Pharmacology of CFTR Chloride
Channel Activity. Physiol. Rev. 79, Suppl.: S109–S144, 1999.—The pharmacology of cystic …

Determining how the regulation of cellular processes is impacted in cystic fibrosis (CF) is
fundamental to understanding disease pathology and to identifying new therapeutic targets …

Compounds that enhance either the function or biosynthetic processing of the cystic fibrosis
transmembrane conductance regulator (CFTR) Cl–channel may be of value in developing …

Summary Background TMEM 16A, a Ca‐activated Cl channel, regulates various
physiological functions such as mucin secretion. However, the role of TMEM 16A in hyper …

1. The disulphonic stilbenes 4, 4'‐dinitrostilbene‐2, 2'‐disulphonic acid (DNDS) and 4, 4'‐
diisothiocyanostilbene‐2, 2'‐disulphonic acid (DIDS) were shown to cause a voltage …

Both secretion and absorption of NaC1 are basic functions of epithelial cells. These
transport processes require polarized insertion of proteins specialized in ion transport to …

The bicyclic fatty acid lubiprostone (formerly known as SPI-0211) activates two types of
anion channels in A6 cells. Both channel types are rarely, if ever, observed in untreated …

Human airway serous cells secrete antibiotic-rich fluid, but, in cystic fibrosis (CF), Cl−-
dependent fluid secretion is impaired by defects in CF transmembrane conductance …

1 There is evidence that defective submucosal gland secretion contributes to the airway
pathology of cystic fibrosis (CF). Using a capacitance probe technique, we have compared …