Aberrant metabolism is a hallmark of cancer, but whole metabolomic flux measurements
remain scarce. To bridge this gap, we developed a novel metabolic phenotypic analysis …

The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1
expression on pathobiology and clinical response to statins in breast cancer needs …

Advances in cell metabolism over the past few decades have demonstrated glutamine as an
essential nutrient for cancer cell survival and proliferation. Glutamine offers a remarkable …

Purpose: Although breast cancers are known to be molecularly heterogeneous, their
metabolic phenotype is less well-understood and may predict response to chemotherapy …

Breast cancer (BC) has replaced lung cancer as the most common cancer worldwide.
Ginsenoside CK (CK) can effectively inhibit triple-negative breast cancer (TNBC), the …

The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) through
genetic engineering is one of the most promising new therapies for treating cancer patients …

Purpose: Glutamine is a critical fuel for solid tumors. Interference with glutamine metabolism
is deleterious to neoplasia in preclinical models. A phase I study of the oral, first-in-class …

Metabolic reprogramming of amino acids has been increasingly recognized to initiate and
fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of …

The acquisition of and departure from stemness in cancer tissues might not only be
hardwired by genetic controllers, but also by the pivotal regulatory role of the cellular …

Simple Summary Mitochondria, often called “the powerhouse of the cell”, generate most of
the energy required for all cellular processes. Mitochondria also provide a platform for …