T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination

R da Silva Antunes, E Garrigan, LG Quiambao… - Cell Host & Microbe, 2023 - cell.com
The incidence of whooping cough due to Bordetella pertussis (BP) infections has increased
recently. It is believed that the shift from whole-cell pertussis (wP) vaccines to acellular …

Safety and immunogenicity of live, attenuated intranasal Bordetella pertussis vaccine (BPZE1) in healthy adults

CB Creech, N Jimenez-Truque, N Kown, K Sokolow… - Vaccine, 2022 - Elsevier
Background BPZE1 is a live, attenuated pertussis vaccine derived from B. pertussis strain
Tohama I modified by genetic removal or inactivation of 3 B. pertussis toxins: pertussis toxin …

[HTML][HTML] Genome-wide characterization of T cell responses to Bordetella pertussis reveals broad reactivity and similar polarization irrespective of childhood …

R da Silva Antunes, E Garrigan, LG Quiambao… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The incidence of whooping cough (pertussis), the respiratory disease caused by Bordetella
pertussis (BP) has increased in recent years, and it is suspected that the switch from whole …

[HTML][HTML] Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: A …

G Pérez Chacón, MJ Estcourt, J Totterdell… - PLoS …, 2024 - journals.plos.org
Background In many countries, infant vaccination with acellular pertussis (aP) vaccines has
replaced use of more reactogenic whole-cell pertussis (wP) vaccines. Based on …

[HTML][HTML] Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy

P Versteegen, AA Bonačić Marinović… - Vaccines, 2022 - mdpi.com
Booster vaccinations for pertussis are advised in many countries during childhood or
adulthood. In a phase IV longitudinal interventional study, we assessed long-term immunity …