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Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

The humoral arm of innate immunity includes diverse molecules with antibody-like functions,
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …

Abstract Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity,
involved in resistance to selected pathogens and in the regulation of inflammation,–. The …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Single-cell transcriptomics promise to revolutionize our understanding of the vasculature.
Emerging computational methods applied to high-dimensional single-cell data allow …

Aging is a key aspect of neoplasia at the level of cells, individuals and populations.
Unrestrained expression and production of inflammatory mediators is a key feature of aging …