The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

[HTML][HTML] In vitro Label Free Raman Microspectroscopic Analysis to Monitor the Uptake, Fate and Impacts of Nanoparticle Based Materials

HJ Byrne, F Bonnier, E Efeoglu, C Moore… - … in Bioengineering and …, 2020 - frontiersin.org
The continued emergence of nanoscale materials for nanoparticle-based therapy, sensing
and imaging, as well as their more general adoption in a broad range of industrial …

Exploiting blood transport proteins as carborane supramolecular vehicles for boron neutron capture therapy

TD Marforio, EJ Mattioli, F Zerbetto, M Calvaresi - Nanomaterials, 2023 - mdpi.com
Carboranes are promising agents for applications in boron neutron capture therapy (BNCT),
but their hydrophobicity prevents their use in physiological environments. Here, by using …

Metallodrugs against Breast Cancer: Combining the Tamoxifen Vector with Platinum (II) and Palladium (II) Complexes

A Kazimir, B Schwarze, P Lönnecke, S Jelača… - Pharmaceutics, 2023 - mdpi.com
The luminal A-subtype of breast cancer, where the oestrogen receptor α (ERα) is
overexpressed, is the most frequent one. The prodrug tamoxifen (1) is the clinically used …

Structural patterns enhancing the antibacterial activity of metallacarborane-based antibiotics

J Cebula, K Fink, W Goldeman… - Journal of Medicinal …, 2023 - ACS Publications
Healthcare systems heavily rely on antibiotics to treat bacterial infections, but the
widespread presence of multidrug-resistant bacteria puts this strategy in danger. Novel …

Expanding the range of bioorthogonal tags for multiplex stimulated Raman scattering microscopy

N Murphy, WJ Tipping, HJ Braddick… - Angewandte …, 2023 - Wiley Online Library
Multiplex optical detection in live cells is challenging due to overlapping signals and poor
signal‐to‐noise associated with some chemical reporters. To address this, the application of …

Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …

Ruthenacarborane–phenanthroline derivatives as potential metallodrugs

M Kellert, I Sárosi, R Rajaratnam, E Meggers… - Molecules, 2020 - mdpi.com
Ruthenium-based complexes have received much interest as potential metallodrugs. In this
work, four RuII complexes bearing a dicarbollide moiety, a carbonyl ligand, and a …

Radioactive Nano-and Microparticles Released from Fukushima Daiichi: Technical Challenges of Multiple Analytic Techniques

S Utsunomiya, K Fueda, K Minomo, K Horie… - 2022 - books.rsc.org
A total activity of∼ 10 19 Bq, including∼ 10 16 Bq of 137 Cs, was released from the
Fukushima Daiichi Nuclear Power Plant (FDNPP) in 2011, among which 137 Cs (30.1 years …

Dosimetry and Imaging of Micro and Nanoparticles by Means of High Resolution Techniques

T Venus, T Meyer, C Zilberfain, J Böttner, A Lampen… - 2022 - books.rsc.org
One of the most pressing issues nowadays is to control and reduce environmental pollution
produced by human activities through industrialization and urbanization. Apart from gaseous …