Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

KRAS is the most frequently mutated driver of pancreatic, colorectal, and non–small cell lung
cancers. Direct KRAS blockade has proved challenging, and inhibition of a key downstream …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy, while the multifaceted roles of SHP2 complicate the drug discovery …

Activating KRAS mutations are present in 25% of human cancer. Although oncogenic Ras
was deemed" undruggable" in the past, recent efforts led to the development of …

Phosphorylation as a post-translational modification is critical for cellular homeostasis.
Kinases and phosphatases regulate phosphorylation levels by adding or removing …

Simple Summary A better understanding of the role of KRAS and its different mutations has
led to the development of specific small-molecule inhibitors able to target KRAS G12C, an …

Both Src homology-2 domain-containing phosphatase 2 (SHP2) and histone deacetylase
(HDAC) are important oncoproteins and potential immunomodulators. In this study, we first …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy. The dynamic change of SHP2 between closed and open …

Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …