Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Formation of the human heart involves complex biological signals, interactions, specification
of myocardial progenitor cells, and heart tube looping. To facilitate survival in the hypoxemic …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

INTRODUCTION The vertebrate heart is composed of diverse cell types, all essential for
normal cardiac function. In the mouse, the earliest mesodermal progenitors of …

Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …

Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

In the past few decades, cardiac regeneration has been the central target for restoring the
injured heart. In mammals, cardiomyocytes are terminally differentiated and rarely divide …

The diversity of cardiac lineages contributes to the heterogeneity of human induced
pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs). Here, we report the generation …

A fundamental challenge in understanding cardiac biology and disease is that the
remarkable heterogeneity in cell type composition and functional states have not been well …