We have developed a new technique for measurements of piconewton forces and
nanometer displacements in the millisecond time range caused by actin-myosin interaction …

In 10-30% of hypertrophic cardiomyopathy kindreds, the disease is caused by> 29 missense
mutations in the cardiac beta-myosin heavy chain (MYH7) gene. The amino acid sequence …

WITHIN the past few years, members of the hedgehog (hh) family of secreted signalling
proteins have emerged as the primary signals generated by certain embryonic patterning …

A quantitative stochastic model of the mechanochemical cycle of myosin, the protein that
drives muscle contraction, is proposed. It is based on three premises:(i) the myosin head …

This review describes the early beginnings of X‐ray diffraction work on muscle structure and
the contraction mechanism in the MRC Unit in the Cavendish Laboratory, Cambridge, and …

During skeletal muscle contraction, regular arrays of actin and myosin filaments slide past
each other driven by the cyclic ATP-dependent interaction of the motor protein myosin II (the …

Blebbistatin is a small molecule inhibitor discovered in a screen for inhibitors of nonmuscle
myosin IIA. Blebbistatin inhibits the actin-activated MgATPase activity and in vitro motility of …

All aspects of cellular RNA metabolism and processing involve DExH/D proteins, which are
a family of enzymes that unwind or manipulate RNA in an ATP-dependent fashion. DExH/D …

KINESIN is a mechanoenzyme which uses energy liberated from ATP hydrolysis to transport
particles towards the'plus ends' of microtubules1–6. The enzyme consists of two polypeptide …

The three-dimensional structures of the truncated myosin head from Dictyostelium
discoideum myosin II (S1dC) complexed with MgAMPPNP, MgATPγS, and MgADP are …