The elementary events in energy transduction by the actomyosin motor, driven by ATP
hydrolysis, were directly recorded from multiple and single molecules using a recently …

Molecular motors are responsible for numerous cellular processes from cargo transport to
heart contraction. Their interactions with other cellular components are often transient and …

MUSCLE contraction occurs by mutual sliding between thick (myosin) and thin (actin)
filaments1, 2. But the physical and chemical properties of the sliding force are not clear; …

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause
of arrhythmias and heart failure. Clinically, HCM is characterized as causing …

Several mutations in the β-myosin heavy chain gene cause hypertrophic cardiomyopathy.
This study investigates (1) the in vitro velocities of translocation of fluorescently-labelled …

Kinesin is a mechanochemical protein that converts the chemical energy in adenosine
triphosphate into mechanical force for movement of cellular components along microtubules …

An in vitro motility assay has been developed in which single actin filaments move on one or
a few heavy meromyosin (HMM) molecules. This movement is slower than when many HMM …

kD-calmodulin, when immobilized on nitrocellulose-coated coverslips, translocates actin
filaments at a maximal rate of 0.07-0.1 micron/s at 37 degrees C. Actin activates MgATPase …

Myosin is one of only three proteins known to convert chemica! energy into mechanical
work. Although the chemical, kinetic and physiological characteristics of this protein have …

ATP consumption and force development were determined in single skinned muscle fibres
of the rat at 12 degrees C. Myofibrillar ATPase consumption was measured photometrically …