Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular
disease, with a prevalence of more than one in 500 individuals worldwide. Genetically …

110-kD-calmodulin, when immobilized on nitrocellulose-coated coverslips, translocates
actin filaments at a maximal rate of 0.07-0.1 micron/s at 37 degrees C. Actin activates …

Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …

The swinging crossbridge hypothesis states that energy from ATP hydrolysis is transduced
to mechanical movement of the myosin head while bound to actin. The light chain-binding …

Fascin‐1 is a putative bundling factor of actin filaments in the filopodia of neuronal growth
cones. Here, we examined the structure of the actin bundle formed by human fascin‐1 …

The discovery of highly efficient gene targeting in Dictyostelium (De Lozanne and Spudich,
1987) and the use of the antisense RNA approach in this organism (Knecht and Loomis …

It has been known for a number of years that calcium ions play a crucial role in excitation-
contraction (ec) coupling (Sandow, 1952). The majority of the calcium required for this …

We have used two in vitro motility assays to study the relative movement of actin and myosin
from turkey gizzards (smooth muscle) and human platelets. In the Nitella-based in vitro …

By comparing the structure of wild-type and mutant muscle myosin heavy chain (MHC)
genes of Drosophila melanogaster, we have identified the defect in the homozygous-viable …

Aberrant actomyosin interactions contribute to a wide range of pathophysiological conditions
including heart failure, neurodegenerative disorders, and tumor growth. Despite surgical …