Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

E Pajarillo, I Nyarko-Danquah, A Digman… - Frontiers in …, 2022 - frontiersin.org
Chronic exposure to elevated levels of manganese via occupational or environmental
settings causes a neurological disorder known as manganism, resembling the symptoms of …

Signaling Pathways Involved in Manganese-Induced Neurotoxicity

H Cheng, BF Villahoz, RD Ponzio, M Aschner, P Chen - Cells, 2023 - mdpi.com
Manganese (Mn) is an essential trace element, but insufficient or excessive bodily amounts
can induce neurotoxicity. Mn can directly increase neuronal insulin and activate insulin-like …

Transcriptome and proteomics conjoint analysis reveal metastasis inhibitory effect of 6-shogaol as ferroptosis activator through the PI3K/AKT pathway in human …

RH Ma, ZJ Ni, K Thakur, CL Cespedes-Acuña… - Food and Chemical …, 2022 - Elsevier
Endometrial cancer remains as one of the widespread female malignancies despite the
existing treatment measures mainly surgery, radiotherapy, and chemotherapy. In recent …

Mechanism by which HDAC3 regulates manganese induced H3K27ac in SH-SY5Y cells and intervention by curcumin

Y Liu, H Zhao, Y Yang, Y Liu, CY Ao, JM Zeng… - Archives of Biochemistry …, 2024 - Elsevier
Long-term excessive exposure to manganese can impair neuronal function in the brain, but
the underlying pathological mechanism remains unclear. Oxidative stress plays a central …

Protective effects of sodium para-aminosalicylic acid on lead and cadmium co-exposure in SH-SY5Y cells

JC Peng, Y Deng, HX Song, YY Fang, CL Gan, JJ Lin… - Brain Sciences, 2023 - mdpi.com
Background: Combined exposure to lead and cadmium is common in occupational
environments. However, the effects of co-exposure to Pb-Cd on neurotoxicity have not been …

Biphasic Dose-Response of Mn-Induced Mitochondrial Damage, PINK1/Parkin Expression, and Mitophagy in SK-N-SH Cells

Y Zhang, HT Hu, YM Cao, ZG Jiang, J Liu… - Dose …, 2023 - journals.sagepub.com
Excessive manganese (Mn) exposure produces neurotoxicity with mitochondrial damage.
Mitophagy is a protective mechanism to eliminate damaged mitochondria to protect cells …

Ferroptosis at the crossroads of manganese-induced neurotoxicity: A retrospective study

Y Liu, S Lv, G He, C Wang, C Ou - Toxicology, 2024 - Elsevier
Manganese is an essential trace element, but overexposure can cause neurotoxicity and
subsequent neurodegenerative diseases. Ferroptosis is a form of cell death characterized …

Flavonoid Compounds in Hippophae rhamnoides L. Protect Endothelial Cells from Oxidative Damage Through the PI3K/AKT‐eNOS Pathway

M Wang, X Zhang, Z Zhang, L Tong, S Yu… - Chemistry & …, 2024 - Wiley Online Library
Sea buckthorn, a traditional medicinal plant, has been used for several years in China for
the prevention and treatment of various diseases, a practice closely associated with its …

[HTML][HTML] Manganese overexposure results in ferroptosis through the HIF-1α/p53/SLC7A11 pathway in ICR mouse brain and PC12 cells

J Chen, Z Tao, X Zhang, J Hu, S Wang, G Xing… - Ecotoxicology and …, 2024 - Elsevier
Manganese (Mn) overexposure has been associated with the development of neurological
damage reminiscent of Parkinson's disease, while the underlying mechanisms have yet to …

Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy

Y Zhang, X Wu, W Yao, Y Ni, X Ding - Pharmaceutical Biology, 2024 - Taylor & Francis
Context Diabetic peripheral neuropathy (DPN) results in an enormous burden and reduces
the quality of life for patients. Considering there is no specific drug for the management of …