Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges
worldwide due to their high morbidity and mortality and limitations in clinical treatment …

The roots and rhizomes of Rhodiola rosea L.(Crassulaceae), which is widely growing in
Northern Europe, North America, and Siberia, have been used since ancient times to …

Mitochondrial dysfunction has been reported to be involved in the pathogenesis of
depression, and mitophagy is a key pathway for mitochondrial quality control. This study …

BACKGROUND Fluoxetine is one of the most widely prescribed anti-depressant drugs
belonging to the category of selective serotonin reuptake inhibitors. Long-term fluoxetine …

In recent years, the use of natural compounds as adjuvant treatments and alternatives to
traditional pharmacological therapies has become increasingly popular. These compounds …

Phenotypic frailty is characterized by a progressive decline in physical functioning. During
ageing, morphological and functional alterations involve the brain, and chief theories involve …

Ethnopharmacological relevance Stroke is one of the leading causes of death and disability.
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …

Wide experimental evidence has been provided in the last decade concerning the
neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders …

Depression is a psychiatric disorder affecting the lives of patients and their families
worldwide. It is an important pathophysiology; however, the molecular pathways involved …

Medicinal plants and their extracts are natural remedies with enormous potential for treating
various diseases, including depression and anxiety. In the case of depression, hundreds of …