[HTML][HTML] Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Effects of mesenchymal stem cell‐derived paracrine signals and their delivery strategies

C Chang, J Yan, Z Yao, C Zhang, X Li… - Advanced healthcare …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

[HTML][HTML] Engineering exosomes and biomaterial-assisted exosomes as therapeutic carriers for bone regeneration

Y Lu, Z Mai, L Cui, X Zhao - Stem cell research & therapy, 2023 - Springer
Mesenchymal stem cell-based therapy has become an effective therapeutic approach for
bone regeneration. However, there are still limitations in successful clinical translation …

Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications

MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Progress in the use of dental pulp stem cells in regenerative medicine

E Anitua, M Troya, M Zalduendo - Cytotherapy, 2018 - Elsevier
The field of tissue engineering is emerging as a multidisciplinary area with promising
potential for regenerating new tissues and organs. This approach requires the involvement …

[HTML][HTML] Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

F Pischiutta, E Caruso, H Cavaleiro, AJ Salgado… - Experimental …, 2022 - Elsevier
The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

[HTML][HTML] Heterogeneity of in vitro expanded mesenchymal stromal cells and strategies to improve their therapeutic actions

L Olmedo-Moreno, Y Aguilera, C Baliña-Sánchez… - Pharmaceutics, 2022 - mdpi.com
Beneficial properties of mesenchymal stromal cells (MSCs) have prompted their use in
preclinical and clinical research. Accumulating evidence has been provided for the …

[HTML][HTML] Dental mesenchymal stem cell secretome: An intriguing approach for neuroprotection and neuroregeneration

A Gugliandolo, E Mazzon - International journal of molecular sciences, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) are known for their beneficial effects and regenerative
potential. In particular, dental-derived MSCs have the advantage of easier accessibility and …

[HTML][HTML] Hypoxia induces DPSC differentiation versus a neurogenic phenotype by the paracrine mechanism

S Delle Monache, F Pulcini, F Santilli, S Martellucci… - Biomedicines, 2022 - mdpi.com
As previously described by several authors, dental pulp stem cells (DPSCs), when
adequately stimulated, may acquire a neuronal-like phenotype acting as a favorable source …