[HTML][HTML] Calcium signaling in Alzheimer's disease & therapies
Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …
essential for cellular homeostasis, development, and stress responsiveness. In response to …
Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models
KS Lee, S Huh, S Lee, Z Wu, AK Kim… - Proceedings of the …, 2018 - National Acad Sciences
Calcium (Ca2+) homeostasis is essential for neuronal function and survival. Altered Ca2+
homeostasis has been consistently observed in neurological diseases. How Ca2+ …
homeostasis has been consistently observed in neurological diseases. How Ca2+ …
Bioinorganic chemistry of Alzheimer's disease
KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease
E Area‐Gomez, M del Carmen Lara Castillo… - The EMBO …, 2012 - embopress.org
Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor
protein (APP) by γ‐secretase, via an unknown mechanism. We recently showed that …
protein (APP) by γ‐secretase, via an unknown mechanism. We recently showed that …
The adverse effects of air pollution on the nervous system
Exposure to ambient air pollution is a serious and common public health concern associated
with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air …
with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air …
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys
Alzheimer's disease (AD) and type 2 diabetes appear to share similar pathogenic
mechanisms. dsRNA-dependent protein kinase (PKR) underlies peripheral insulin …
mechanisms. dsRNA-dependent protein kinase (PKR) underlies peripheral insulin …
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
D Kapogiannis, MP Mattson - The Lancet Neurology, 2011 - thelancet.com
Epidemiological, neuropathological, and functional neuroimaging evidence implicates
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …
an overwhelming health, social, economic, and political problem to nations. Unless a new …
Challenges for Alzheimer's disease therapy: insights from novel mechanisms beyond memory defects
Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …
more prevalent by midcentury, constituting a major global health concern with huge …