The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease

I Fleming - Pharmacological reviews, 2014 - ASPET
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

CYP/PON genetic variations as determinant of organophosphate pesticides toxicity

G Kaur, AK Jain, S Singh - Journal of genetics, 2017 - Springer
In the present scenario of increased accumulation of pesticides in the environment, it is
important to understand its impact on human health. The focus is on gene–environment …

Personalized antiplatelet therapy according to CYP2C19 genotype after percutaneous coronary intervention: a randomized control trial

X Xie, YT Ma, YN Yang, XM Li, YY Zheng, X Ma… - International journal of …, 2013 - Elsevier
Objective The objective of this study is to compare personalized antiplatelet therapy
according to CYP2C19 phenotype with conventional antiplatelet therapy in patients after …

Impact of smoking on the eradication of Helicobacter pylori

J Yu, P Yang, X Qin, C Li, Y Lv, X Wang - Helicobacter, 2022 - Wiley Online Library
Abstract Background and Aim Although the association between the eradication of
Helicobacter pylori (H. pylori) and smoking has been confirmed through a meta‐analysis …

CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study

N Cai, C Li, X Gu, W Zeng, J Zhong, J Liu… - BMC Cardiovascular …, 2023 - Springer
Background Genetic factors have a certain proportion in the risk factors of hypertension. The
purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) …

Smoking increases the likelihood of Helicobacter pylori treatment failure

D Itskoviz, D Boltin, H Leibovitzh, TT Perets… - Digestive and Liver …, 2017 - Elsevier
Background and aims Data regarding the impact of smoking on the success of Helicobacter
pylori (H. pylori) eradication are conflicting, partially due to the fact that sociodemographic …

Gene–gene and gene–environment interactions defining lipid-related traits

JM Ordovás, R Robertson… - Current opinion in …, 2011 - journals.lww.com
Epigenetic and epistatic interactions are now becoming more significantly associated with
such disorders, as genomic research digs deeper into the complex nature of genetic …

Genetic variation in NFKB1 and NFKBIA and susceptibility to coronary artery disease in a Chinese Uygur population

HM Lai, XM Li, YN Yang, YT Ma, R Xu, S Pan, H Zhai… - PloS one, 2015 - journals.plos.org
Objectives Coronary artery disease (CAD) is the most common chronic inflammatory
disease worldwide. NF-κ B, a central regulator of inflammation, is involved in various …

CYP2C19 phenotype, stent thrombosis, myocardial infarction, and mortality in patients with coronary stent placement in a Chinese population

X Xie, YT Ma, YN Yang, XM Li, X Ma, ZY Fu… - PLoS …, 2013 - journals.plos.org
Background Several studies have indicated that CYP2C19 loss-of-function polymorphisms
have a higher risk of stent thrombosis (ST) after percutaneous coronary interventions (PCIs) …

Alcohol consumption and ankle-to-brachial index: results from the cardiovascular risk survey

X Xie, YT Ma, YN Yang, XM Li, F Liu, D Huang, ZY Fu… - PloS one, 2010 - journals.plos.org
Background and Methodology A low ankle-to-brachial index (ABI) is a strong correlate of
cardiovascular disease and subsequent mortality. The relationship between ABI and alcohol …