The C-terminal domain of RNA Pol II helps ensure that editing precedes splicing of the GluR-B transcript
K Ryman, N Fong, E Bratt, DL Bentley, M Öhman - Rna, 2007 - rnajournal.cshlp.org
The C-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II) influences
many steps in the synthesis of an mRNA and helps control the final destiny of the mature …
many steps in the synthesis of an mRNA and helps control the final destiny of the mature …
The last CTD repeat of the mammalian RNA polymerase II large subunit is important for its stability
RD Chapman, B Palancade, A Lang… - Nucleic acids …, 2004 - academic.oup.com
The phosphorylation of the RNA polymerase II (Pol II) C‐terminal domain (CTD) has been
shown to affect the initiation, and transition to elongation of the Pol II complex. The …
shown to affect the initiation, and transition to elongation of the Pol II complex. The …
The two steps of poly (A)-dependent termination, pausing and release, can be uncoupled by truncation of the RNA polymerase II carboxyl-terminal repeat domain
NJ Park, DC Tsao, HG Martinson - Molecular and cellular biology, 2004 - Taylor & Francis
The carboxyl-terminal repeat domain (CTD) of RNA polymerase II is thought to help
coordinate events during RNA metabolism. The mammalian CTD consists of 52 imperfectly …
coordinate events during RNA metabolism. The mammalian CTD consists of 52 imperfectly …
Effects of phosphorylation by protein kinase CK2 on the human basal components of the RNA polymerase II transcription machinery
ME Cabrejos, CC Allende… - Journal of cellular …, 2004 - Wiley Online Library
We have investigated the role of phosphorylation by vertebrate protein kinase CK2 on the
activity of the General Transcription Factors TFIIA, TFIIE, TFIIF, and RNAPII. The largest …
activity of the General Transcription Factors TFIIA, TFIIE, TFIIF, and RNAPII. The largest …
Cyclin-dependent kinase-9: an RNAPII kinase at the nexus of cardiac growth and death cascades
M Sano, MD Schneider - Circulation research, 2004 - Am Heart Assoc
Over the past decade and a half, the paradigm has emerged of cardiac hypertrophy and
ensuing heart failure as fundamentally a problem in signal transduction, impinging on the …
ensuing heart failure as fundamentally a problem in signal transduction, impinging on the …
[HTML][HTML] The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3′ end formation
RNA polymerase II plays a critical role not only in transcription of mRNA precursors but also
in their subsequent processing. This later function is mediated primarily by the C-terminal …
in their subsequent processing. This later function is mediated primarily by the C-terminal …
[HTML][HTML] N-terminal tagging of RNA Polymerase II shapes transcriptomes more than C-terminal alterations
A Callan-Sidat, E Zewdu, M Cavallaro, J Liu… - Iscience, 2024 - cell.com
Summary RNA polymerase II (Pol II) has a C-terminal domain (CTD) that is unstructured,
consisting of a large number of heptad repeats, and whose precise function remains …
consisting of a large number of heptad repeats, and whose precise function remains …
[HTML][HTML] RNA Polymerase II evolution and adaptations: Insights from Plasmodium and other parasitic protists
D Purkayastha, K Karmodiya - Infection, Genetics and Evolution, 2023 - Elsevier
The C-terminal domain (CTD) of RNA polymerase II plays a crucial role in regulating
transcription dynamics in eukaryotes. The phosphorylation of serine residues within the CTD …
transcription dynamics in eukaryotes. The phosphorylation of serine residues within the CTD …
[HTML][HTML] Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns
Splicing of mRNA precursors is essential in the regulation of gene expression. U2AF65
recognizes the poly-pyrimidine tract and helps in the recognition of the branch point …
recognizes the poly-pyrimidine tract and helps in the recognition of the branch point …
BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels
A Moisan, C Larochelle, B Guillemette… - Molecular and cellular …, 2004 - Taylor & Francis
A high incidence of breast and ovarian cancers has been linked to mutations in the BRCA1
gene. BRCA1 has been shown to be involved in both positive and negative regulation of …
gene. BRCA1 has been shown to be involved in both positive and negative regulation of …