Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived
with a circulating half life of 6–8h and hence are produced at a rate of 5× 10 10–10× 10 10 …

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …

The term congenital neutropenia encompasses a family of neutropenic disorders, both
permanent and intermittent, severe (< 0.5 G/l) or mild (between 0.5-1.5 G/l), which may also …

Highlights•Current mechanistic understanding of granulocyte colony-stimulating factor
receptor (G-CSFR) signaling is presented.•Clinical consequences of G-CSFR mutations and …

A considerable amount of continuous proliferation and differentiation is required to produce
daily a billion new neutrophils in an adult human. Of the few cytokines and factors known to …

Although historically viewed as merely anti-microbial effectors in acute infection or injury,
neutrophils are now appreciated to be functionally versatile with critical roles also in chronic …

Neutrophils are key pathogen exterminators of the innate immune system endowed with
oxidative and non-oxidative defense mechanisms. More recently, a more complex role for …

Granulocyte colony-stimulating factor plays a central role in the dynamic regulation of
neutrophil production and release from the bone marrow in response to environmental …