Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is
active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism …

The main challenges for programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) checkpoint
blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive …

The tumor milieu consists of numerous cell types each existing in a different environment.
However, a characterization of metabolic heterogeneity at single-cell resolution is not …

Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

Over the past 15 years, there has been great interest in the potential to repurpose the
diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts …

Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …

Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …

Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare.
Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary …

Autophagy is an evolutionarily conserved lysosome-or vacuole-dependent catabolic
pathway in eukaryotes. Autophagy functions basally for cellular quality control and is …