The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …

Iron is one of the major limiting factors and essential nutrients of microbial life. Since in
nature it is not readily available in the preferred form, microorganisms produce small high …

Hydroxamic acids are an important class of molecules, in particular because of their metal-
chelating ability. Microorganisms, including pathogenic bacteria, use hydroxamate-based …

Antibiotic resistance is a global health concern and a current threat to modern medicine and
society. New strategies for antibiotic drug design and delivery offer a glimmer of hope in a …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

The ability of bacteria to develop resistance to antimicrobial agents poses problems in the
treatment of numerous bacterial infections. One method to circumvent permeability-mediated …

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen responsible for
nosocomial infections. The prevalence of antibiotic-resistant P. aeruginosa strains is …

Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …

Many antibiotics lack activity against Gram-negative bacteria because they cannot permeate
the outer membrane or suffer from efflux and, in the case of β-lactams, are degraded by β …

β-lactam antibiotics are among the most important and widely used antimicrobials worldwide
and are comprised of a large family of compounds, obtained by chemical modifications of …