Targeted assembly of nanoparticles in biological systems holds great promise for disease-
specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is …

As the landscape of macromolecule therapeutics advances, drug developers are continuing
to aim at intracellular targets. To activate, inhibit, or degrade these targets, the …

In recent years, organic fluorophores-based molecular probes with dual-fluorescence
ratiometric responses to in-vitro/in-vivo pH (DFR-MPs-pH) have been attracting much …

Galactose as a recognizing motif for asialoglycoprotein receptor (ASGPR) is a widely
accepted vector to deliver cytotoxic agents in the therapy of hepatocellular carcinoma …

In this work, we introduce ratiometric diffuse in vivo flow cytometry (R-DiFC) for quantitative
measurement of circulating fluorescent red blood cell (fRBC) sensors for systemic blood …

A major obstacle in biotherapeutics development is maximizing cell penetration. Ideally,
assays would allow for optimization of cell penetration in the cell type of interest early in the …

Fluorophores with color‐shifting characteristics have attracted enormous research interest in
the quantitative application of RNA sensors. It reports here a simple synthesis, luminescent …

Abstract Diffuse in vivo Flow Cytometry (DiFC) is an optical technique that allows continuous
monitoring of fluorescent cells in the blood. So far, this technology has mainly been used to …