Plastin 3 (PLS3) is an F-actin-bundling protein that has gained attention as a modifier of
spinal muscular atrophy (SMA) pathology. SMA is a lethal pediatric neuromuscular disease …

Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutations in the
SMN1 gene. Being a monogenic disease, it is characterized by high clinical heterogeneity …

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by loss of survival
motor neuron-1 (SMN1). A nearly identical copy gene, SMN2, is present in all SMA patients …

Spinal muscular atrophy (SMA) is caused by mutations that reduce the level of the survival
motor neuron protein (SMN) resulting in death of alpha-motor neurons, yet it is unclear why …

Spinal muscular atrophy (SMA) is a devastating genetic motoneuron disease leading to
infant death. No effective therapy is currently available. It has been suggested that β-lactam …

The actin-binding and bundling protein, plastin 3 (PLS3), was identified as a protective
modifier of spinal muscular atrophy (SMA) in some patient populations and as a disease …

Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with
concomitant muscle denervation. MN excitability and vulnerability to disease are particularly …

Reduced levels of the SMN (survival of motoneuron) protein cause spinal muscular atrophy,
the main form of motoneuron disease in children and young adults. In cultured motoneurons …

Proper function of the motor unit is dependent upon the correct development of dendrites
and axons. The infant/childhood onset motoneuron disease spinal muscular atrophy (SMA) …

Spontaneous Ca2+ transients and actin dynamics in primary motoneurons correspond to
cellular differentiation such as axon elongation and growth cone formation. Brain-derived …