Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery
S Gao, X Liu, T Li, L Chen, Y Feng, Y Wang… - Acta Pharmacologica …, 2024 - nature.com
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …
[HTML][HTML] The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitus
K Wu, Y Wang, R Liu, H Wang, T Rui - Frontiers in Physiology, 2023 - frontiersin.org
Cardiovascular diseases are severe diseases posing threat to human health because of
their high morbidity and mortality worldwide. The incidence of diabetes mellitus is also …
their high morbidity and mortality worldwide. The incidence of diabetes mellitus is also …
Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice
L Liu, K Sun, Y Luo, B Wang, Y Yang, L Chen, S Zheng… - Life Sciences, 2023 - Elsevier
Aims Diabetic cardiomyopathy is a significant contributor to the global pandemic of heart
failure. In the present study we investigated the involvement of myocardin-related …
failure. In the present study we investigated the involvement of myocardin-related …
[HTML][HTML] Diabetic endothelial microangiopathy and pulmonary dysfunction
L Zhang, F Jiang, Y Xie, Y Mo, X Zhang… - Frontiers in …, 2023 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is a widespread metabolic condition with a high global
morbidity and mortality rate that affects the whole body. Their primary consequences are …
morbidity and mortality rate that affects the whole body. Their primary consequences are …
Age-Induced Accumulation of Succinate Promotes Cardiac Fibrogenesis
Z Wang, S Yang, Z Ping, Y Li, T Jiang, X Zheng… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: Age-related cardiac fibrosis is a risk factor for heart failure and a marker for
heart aging. However, the mechanisms underlying age-related cardiac fibrosis remain …
heart aging. However, the mechanisms underlying age-related cardiac fibrosis remain …
[HTML][HTML] Endothelial cell dysfunction in cardiac disease: driver or consequence?
JD Allbritton-King, G García-Cardeña - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
The vascular endothelium is a multifunctional cellular system which directly influences blood
components and cells within the vessel wall in a given tissue. Importantly, this cellular …
components and cells within the vessel wall in a given tissue. Importantly, this cellular …
[HTML][HTML] New insights into the genetics and epigenetics of aging plasticity
J Zhang, S Wang, B Liu - Genes, 2023 - mdpi.com
Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity
for tissue regeneration, and an increased risk of age-related diseases and mortality. A …
for tissue regeneration, and an increased risk of age-related diseases and mortality. A …
[HTML][HTML] A rat model of metabolic syndrome-related heart failure with preserved ejection fraction phenotype: pathological alterations and possible molecular …
Y Shi, C Liu, C Yang, W Qiao, Y Liu, S Liu… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Background Heart failure with preserved ejection fraction (HFpEF) represents a syndrome
involving multiple pathophysiologic disorders and clinical phenotypes. This complexity …
involving multiple pathophysiologic disorders and clinical phenotypes. This complexity …
[HTML][HTML] Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
H Liu, L Sun, H Zhao, Z Zhao, S Zhang… - Cell Death & …, 2024 - nature.com
Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can
transform into leukemic blasts. However, the mechanism that controls differentiation remains …
transform into leukemic blasts. However, the mechanism that controls differentiation remains …
[HTML][HTML] SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma
E Abbotto, C Miro, F Piacente, A Salis, M Murolo… - Biomedicine & …, 2023 - Elsevier
Abstract Sirtuin 6 (SIRT6) has a critical role in cutaneous Squamous Cell Carcinoma
(cSCC): SIRT6 silencing in skin SCC cells has pro-differentiating effects and SIRT6 deletion …
(cSCC): SIRT6 silencing in skin SCC cells has pro-differentiating effects and SIRT6 deletion …