Inflammatory processes in alzheimer's disease—pathomechanism, diagnosis and treatment: a review

B Twarowski, M Herbet - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease

F Zhang, R Zhong, C Cheng, S Li, W Le - Acta Pharmacologica Sinica, 2021 - nature.com
As the population ages, Alzheimer's disease (AD), the most common neurodegenerative
disease in elderly people, will impose social and economic burdens to the world. Currently …

The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer's disease: therapeutic implications and future …

MC Jurcău, FL Andronie-Cioara, A Jurcău, F Marcu… - Antioxidants, 2022 - mdpi.com
Alzheimer's disease (AD), the most common form of dementia, has increasing incidence,
increasing mortality rates, and poses a huge burden on healthcare. None of the currently …

[HTML][HTML] Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access

L Giovannelli, E Bari, C Jommi, F Tartara, D Armocida… - Bioactive Materials, 2023 - Elsevier
Neurodegenerative diseases represent a growing burden on healthcare systems worldwide.
Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their …

[HTML][HTML] MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway

S Ma, X Zhou, Y Wang, Z Li, Y Wang, J Shi, F Guan - Redox Biology, 2022 - Elsevier
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation is a
promising therapy for Alzheimer's disease (AD). However, hUC-MSCs cultured in vitro easily …

Transplantation of nasal olfactory mucosa mesenchymal stem cells benefits Alzheimer's disease

CG Hong, ML Chen, R Duan, X Wang, ZL Pang… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a common neurodegenerative disease that contributes to 60–
70% of dementia in elderly people and is currently incurable. Current treatments only relieve …

Results and insights from a phase I clinical trial of Lomecel‐B for Alzheimer's disease

M Brody, M Agronin, BJ Herskowitz… - Alzheimer's & …, 2023 - Wiley Online Library
Abstract Hypothesis We hypothesized that Lomecel‐B, an allogeneic medicinal signaling
cell (MSC) therapeutic candidate for Alzheimer's disease (AD), is safe and potentially …

Stem cell therapy for Alzheimer's disease: An overview of experimental models and reality

C Qin, K Wang, L Zhang, L Bai - Animal models and …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder. The pathology of AD is
characterized by extracellular amyloid beta (Aβ) plaques, neurofibrillary tangles composed …

The functional mechanism of bone marrow-derived mesenchymal stem cells in the treatment of animal models with Alzheimer's disease: crosstalk between autophagy …

C Qin, L Bai, Y Li, K Wang - Stem cell research & therapy, 2022 - Springer
The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates
neuropathology and improves cognitive deficits in animal models with Alzheimer's disease …

A review of stem cell therapy: an emerging treatment for dementia in alzheimer's and Parkinson's disease

AU Pradhan, O Uwishema, H Onyeaka… - Brain and …, 2022 - Wiley Online Library
Aim This article aims to study the benefits and disadvantages of stem cell therapy, especially
for patients who have dementia. Methods The databases PubMed, Google Scholar, and the …