NSAIDs inhibit tumorigenesis, but how?
E Gurpinar, WE Grizzle, GA Piazza - Clinical cancer research, 2014 - AACR
Numerous epidemiologic studies have reported that the long-term use of nonsteroidal anti-
inflammatory drugs (NSAID) is associated with a significant decrease in cancer incidence …
inflammatory drugs (NSAID) is associated with a significant decrease in cancer incidence …
Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention
SM Fischer, ET Hawk, RA Lubet - Cancer prevention research, 2011 - AACR
Coxibs, including celecoxib, and other nonsteroidal anti-inflammatory drugs (NSAID),
including aspirin, are among the most promising cancer chemopreventive agents in …
including aspirin, are among the most promising cancer chemopreventive agents in …
Chemoprevention of colon cancer by DFMO, Sulindac, and NO-Sulindac administered individually or in combinations in F344 Rats
V Madka, JMR Patlolla, K Venkatachalam, Y Zhang… - Cancers, 2023 - mdpi.com
Simple Summary Colon cancer is a major health problem, and its occurrence is rising
particularly among young adults. Preventing this cancer is urgently needed. Earlier studies …
particularly among young adults. Preventing this cancer is urgently needed. Earlier studies …
[HTML][HTML] Obesity, metabolism and the microenvironment: Links to cancer
S Sundaram, AR Johnson, L Makowski - Journal of carcinogenesis, 2013 - ncbi.nlm.nih.gov
Historically, cancer research has focused on identifying mutations or amplification of genes
within the tumor, which informed the development of targeted therapies against affected …
within the tumor, which informed the development of targeted therapies against affected …
Animal models of colorectal cancer: from spontaneous to genetically engineered models and their applications
E Nascimento-Gonçalves, BAL Mendes… - Veterinary …, 2021 - mdpi.com
Colorectal cancer is one of the most common gastrointestinal malignancies in humans,
affecting approximately 1.8 million people worldwide. This disease has a major social …
affecting approximately 1.8 million people worldwide. This disease has a major social …
Naproxen induces cell-cycle arrest and apoptosis in human urinary bladder cancer cell lines and chemically induced cancers by targeting PI3K
Abstract Naproxen [(S)-6-methoxy-α-methyl-2-naphthaleneacetic acid] is a potent
nonsteroidal anti-inflammatory drug that inhibits both COX-1 and COX-2 and is widely used …
nonsteroidal anti-inflammatory drug that inhibits both COX-1 and COX-2 and is widely used …
Anticancer and antimicrobial activities of naproxen and naproxen derivatives
Mİ Han, ŞG Küçükgüzel - Mini reviews in medicinal chemistry, 2020 - ingentaconnect.com
This review explains the effects of naproxen and the naproxen moiety in important biological
activities. Naproxen, 2-(6-methoxynaphthalen-2-yl) propionic acid, is one of the most utilized …
activities. Naproxen, 2-(6-methoxynaphthalen-2-yl) propionic acid, is one of the most utilized …
[HTML][HTML] Cyclooxygenases: mediators of UV-induced skin cancer and potential targets for prevention
CA Elmets, JJ Ledet, M Athar - Journal of Investigative Dermatology, 2014 - Elsevier
Non-melanoma skin cancers (NMSCs) are among the most common human malignancies.
Current methods for their prevention include avoidance of natural and artificial sources of …
Current methods for their prevention include avoidance of natural and artificial sources of …
Novel metallo-therapeutics of the NSAID naproxen. Interaction with intracellular components that leads the cells to apoptosis
CN Banti, AD Giannoulis, N Kourkoumelis… - Dalton …, 2014 - pubs.rsc.org
Two new mixed ligand–silver (I) complexes of the anti-inflammatory drug naproxen (naprH)
and triphenylphosphine (tpp) or tri (p-tolyl) phosphine (tptp) of formulae {[Ag (tpp) 3 …
and triphenylphosphine (tpp) or tri (p-tolyl) phosphine (tptp) of formulae {[Ag (tpp) 3 …
Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in …
Evidence supports the protective role of nonsteroidal anti-inflammatory drugs (NSAID) and
statins against colon cancer. Experiments were designed to evaluate the efficacies …
statins against colon cancer. Experiments were designed to evaluate the efficacies …