Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA.
An increasing body of literature has demonstrated a major role for IR in numerous biological …

Abstract SAGA (Spt-Ada-Gcn5-Acetyltransferase), an evolutionarily conserved
transcriptional co-activator among eukaryotes, is a large multi-subunit protein complex with …

Most of the transcribed eukaryotic genomes are composed of non-coding transcripts. Among
these transcripts, some are newly transcribed when compared to outgroups and are referred …

The human genome encodes large numbers of non-coding RNAs, including divergent
antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by …

The discovery of a large number of long noncoding RNAs (lncRNAs), and the finding that
they may play key roles in different biological processes, have started to provide a new …

Molecular studies of meiosis in mammals have been long relegated due to some intrinsic
obstacles, namely the impossibility to reproduce the process in vitro, and the difficulty to …

Non-coding natural antisense transcripts (ncNATs) are regulatory RNA sequences that are
transcribed in the opposite direction to protein-coding or non-coding transcripts. These …

Dozens of incurable neurological disorders result from expansion of short repeat sequences
in both coding and non-coding regions of the transcriptome. Short repeat expansions …

Recent large genome-wide association studies have identified multiple confident risk loci
linked to addiction-associated behavioral traits. Most genetic variants linked to addiction …

Background Osteosarcoma is a primary cause of cancer-associated death in children and
adolescents worldwide. Long non-coding RNAs SNHG16 (lncRNA SNHG16) and integrin …