Understanding the mechanism of action and the pharmacokinetic properties of vasodilatory
drugs facilitates optimal use in clinical practice. It should be kept in mind that a drug belongs …

Amyloid β peptide (Aβ) induced toxicity is a well‐established pathway of neuronal cell death
which might play a role in Alzheimer's disease. In this regard, the toxic effect of Aβ on a …

Premature infants have a high incidence of bronchopulmonary dysplasia (BPD). Systemic
hypertension, arterial thickness and stiffness, and increased systemic afterload may all …

This study describes the development and comparison of two HPLC methods for the
analysis of the antihypertensive drug captopril. The first method is based on a precolumn …

During the last decades, the introduction of new, more efficient drugs, has significantly
improved the heart failure (HF) therapy of adults. Therapeutic focus has shifted from simple …

Investigations were performed on representative compounds from five different therapeutic
classes to evaluate the use of categorical data-derived adjustment factors to account for …

We report three cases of angiotensin converting enzyme inhibitor (ACEI) induced
nephrotoxicity in preterm infants with congenital heart disease. Patients developed acute …

The use of blood spot collection cards was investigated as a means of obtaining small
volume samples for the analysis of therapeutic drugs for the purpose of neonatal …

BACKGROUND: Plasma renin activity (PRA) has gained relevance as prognostic marker in
adults with heart failure. The use of PRA as a clinically meaningful parameter in children and …

The use of the angiotensin converting enzyme inhibitor, captopril, specially in children, has
been empirical. This is because the relationship between the pharmacokinetics and …