Advances and future perspectives in epithelial drug delivery
Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …
including xenobiotics, pollen and microbiota. The relative permeability of the various …
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches
Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …
whereas several physiological barriers limit its application via the interaction with inhaled …
An inhalable hybrid biomimetic nanoplatform for sequential drug release and remodeling lung immune homeostasis in acute lung injury treatment
Interactions of lung macrophages and recruited neutrophils with the lung microenvironment
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …
[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …
effects, making it the preferred means of drug delivery for the treatment of respiratory …
Revisiting airflow and aerosol transport phenomena in the deep lungs with microfluidics
J Sznitman - Chemical Reviews, 2021 - ACS Publications
The dynamics of respiratory airflows and the associated transport mechanisms of inhaled
aerosols characteristic of the deep regions of the lungs are of broad interest in assessing …
aerosols characteristic of the deep regions of the lungs are of broad interest in assessing …
[HTML][HTML] Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody
C Li, W Zhan, Z Yang, C Tu, G Hu, X Zhang, W Song… - Cell, 2022 - cell.com
The effectiveness of SARS-CoV-2 vaccines and therapeutic antibodies have been limited by
the continuous emergence of viral variants and by the restricted diffusion of antibodies from …
the continuous emergence of viral variants and by the restricted diffusion of antibodies from …
[HTML][HTML] Inhalable nanoparticle-based dry powder formulations for respiratory diseases: challenges and strategies for translational research
The emergence of novel respiratory infections (eg, COVID-19) and expeditious development
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …
[HTML][HTML] Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening
For the past 50 years, the route of inhalation has been utilized to administer therapies to
treat a variety of respiratory and pulmonary diseases. When compared with other drug …
treat a variety of respiratory and pulmonary diseases. When compared with other drug …
Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …
based approaches aimed to tackle pulmonary ailments in recent years. The current …
Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics
A Artzy-Schnirman, SA Raviv, OD Flikshtain… - Advanced drug delivery …, 2021 - Elsevier
Over the past years, advanced in vitro pulmonary platforms have witnessed exciting
developments that are pushing beyond traditional preclinical cell culture methods. Here, we …
developments that are pushing beyond traditional preclinical cell culture methods. Here, we …