Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to
anticancer agents represents one of the major obstacles for the effective cancer treatment …

Introduction Hybrid drug design has developed as a prime method for the development of
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …

Among the different hallmarks of cancer, deregulation of cellular metabolism turned out to be
an essential mechanism in promoting cancer resistance and progression. The pyruvate …

The inhibition or prevention of biofilm formation represents an emerging strategy in the war
against antibiotic resistance, interfering with key players in bacterial virulence. This …

Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly
involved in altered cancer cell metabolism, resulting in cancer aggressiveness and …

In spite of substantial progress made toward understanding cancer pathogenesis, this
disease remains one of the leading causes of mortality. Thus, there is an urgent need to …

Limited therapeutic options are available for advanced colorectal cancer (CRC). Herein, we
report that exposure to a neo-synthetic bis (indolyl) thiazole alkaloid analog, nortopsentin …

An efficient copper–iodine cocatalyzed intermolecular C–H aminocyanation of indoles with a
broad substrate scope has been developed for the first time. This method enables highly …

Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer,
characterized by late prognosis and drug resistance. Among the main factors sustaining …