Standard chemotherapy and personalized target therapies are commonly used in patients
with advanced non-small cell lung cancer (NSCLC). However, multidrug resistance (MDR) …

In this work, a series of diaryl benzo [b][1, 4] thiazepine derivatives D1-D36 were
synthesized and screened as tubulin polymerization inhibitors with anti-tumor potency. They …

New coordination compounds of copper (II) with 2, 5-bis (ethylthio)-1, 3, 4-thiadiazole (L1)
and 2, 5-bis (pyridylmethylthio)-1, 3, 4-thiadiazole (L2) with compositions Cu (L1) 2Br2, Cu …

Pancreatic cancer (PC) is the seventh most common cause of cancer‑associated mortality
worldwide. The current study aimed to investigate the function and molecular mechanism …

Benzo [1, 2-d: 4, 5-d′] bis ([1, 2, 3] thiadiazole)(isoBBT) is a new electron-withdrawing
building block that can be used to obtain potentially interesting compounds for the synthesis …

In this study, thioether‐bridged imidazo [2, 1‐b][1, 3, 4] thiadiazole derivatives that contained
both imidazole and 1, 3, 4‐thiadiazole (compounds 7a‐7i and 8a‐8i) were synthesized from …

Four series of novel pyrazole derivatives (compounds 17a–m, 18a–m, 19a–g, and 20a–g)
were synthesized, and their antibacterial and antifungal activities were evaluated. Most of …

In this study, a novel series of 2, 6‐disubstituted and 2, 5, 6‐trisubstituted imidazo [2, 1‐b][1,
3, 4] thiadiazole derivatives were synthesized starting from 2‐amino‐1, 3, 4‐thiadiazole …

The present work describes the preparation of bivalent Ni (II), Co (II) and Cu (II) complexes
of [(E)-[(2-methyl-1, 3-thiazol-5-yl) methylidene] amino] thiourea (MTHC) by mixing in 1: 2 …

This study synthesized novel ciprofloxacin analogs bearing the 2-amino-1, 3, 4-thiadiazole
ring, including tryptophan and different sulfonamides, to act as antimicrobial agents. Then …