Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

OXA β-lactamases

BA Evans, SGB Amyes - Clinical microbiology reviews, 2014 - Am Soc Microbiol
The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

[HTML][HTML] Antimicrobial resistance in Acinetobacter baumannii: From bench to bedside

MF Lin, CY Lan - World Journal of Clinical Cases: WJCC, 2014 - ncbi.nlm.nih.gov
Acinetobacter baumannii (A. baumannii) is undoubtedly one of the most successful
pathogens in the modern healthcare system. With invasive procedures, antibiotic use and …

Global evolution of multidrug-resistant Acinetobacter baumannii clonal lineages

R Zarrilli, S Pournaras, M Giannouli… - International journal of …, 2013 - Elsevier
The rapid expansion of Acinetobacter baumannii clinical isolates exhibiting resistance to
carbapenems and most or all available antibiotics during the last decade is a worrying …

Diversity, epidemiology, and genetics of class D β-lactamases

L Poirel, T Naas, P Nordmann - Antimicrobial agents and …, 2010 - Am Soc Microbiol
Class D β-lactamase-mediated resistance to β-lactams has been increasingly reported
during the last decade. Those enzymes also known as oxacillinases or OXAs are widely …

Emerging carbapenemases: a global perspective

TR Walsh - International journal of antimicrobial agents, 2010 - Elsevier
The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged
both the scientific and pharmaceutical sectors. The hallmark of this general increase is the …

The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace

I Roca, P Espinal, X Vila-Farrés, J Vila - Frontiers in microbiology, 2012 - frontiersin.org
During the past few decades Acinetobacter baumannii has evolved from being a commensal
dweller of health-care facilities to constitute one of the most annoying pathogens …

Bench-to-bedside review: the role of β-lactamases in antibiotic-resistant Gram-negative infections

K Bush - Critical care, 2010 - Springer
Multidrug resistance has been increasing among Gram-negative bacteria and is strongly
associated with the production of both chromosomal-and plasmid-encoded β-lactamases …

The rise of carbapenem-resistant Acinetobacter baumannii

BA Evans, A Hamouda… - Current pharmaceutical …, 2013 - ingentaconnect.com
Acinetobacter spp. are Gram-negative bacteria that have become one of the most difficult
pathogens to treat. The species A. baumannii, largely unknown 30 years ago, has risen to …

β-Lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula

HM Zowawi, HH Balkhy, TR Walsh… - Clinical microbiology …, 2013 - Am Soc Microbiol
Infections due to Gram-negative bacilli (GNB) are a leading cause of morbidity and mortality
worldwide. The extent of antibiotic resistance in GNB in countries of the Gulf Cooperation …