Chemokines can induce chemotactic cell migration by interacting with G protein-coupled
receptors to play a significant regulatory role in the development of cancer. CXC chemokine …

The microenvironment within solid tumours can influence the metastatic dissemination of
tumour cells, and recent evidence suggests that poorly oxygenated (hypoxic) cells in primary …

The discovery of novel drug targets is a significant challenge in drug development. Although
the human genome comprises approximately 30,000 genes, proteins encoded by fewer than …

Background SLUG is a zinc-finger transcription factor of the Snail/Slug zinc-finger family that
plays a role in migration and invasion of tumor cells. Mechanisms by which SLUG promotes …

The interaction between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-
1 (SDF-1, also known as CXCL12) is a natural regulatory process in the human body …

Objective: CXCL12 exerts a wide variety of chemotactic effects on cells. Evidence indicates
that CXCL12, in conjunction with its receptor, CXCR4, promotes invasion and metastasis of …

Lung cancer represents the leading cause of cancer-related mortality throughout the world.
Patients die of local progression, disseminated disease, or both. At least one third of the …

As seafood consumption shifts from fisheries harvests to artificially propagated aquatic
species, the increase of aquaculture activities poses a biological threat to our environment …

Lipid membranes have an essential role in most physiological processes including cell
protection, cell-to-cell communication and regulation of intracellular signaling. These …

The etiology of several autoimmune diseases, including multiple sclerosis (MS) is still not
clarified. MS is defined as an autoimmune disease with clinical features of a chronic …